Translational Research
Volume 152, Issue 2 , Pages 67-80 , August 2008

Zinc supplementation decreases oxidative stress, incidence of infection, and generation of inflammatory cytokines in sickle cell disease patients

Received 7 February 2008 ,Revised 2 June 2008 ,Accepted 4 June 2008.

References 

  1. Prasad AS, Miale A, Farid Z, Sandstead HH, Schulert AR. Zinc metabolism in patients with the syndrome of iron deficiency anemia, hepatosplenomegaly, hypogonadism, and dwarfism. J Lab Clin Med. 1963;61:537–549
  2. Prasad AS. Biochemistry of zinc. New York: Plenum; 1993;
  3. Prasad AS, Schoomaker EB, Ortega J, Brewer GJ, Oberleas D, Oeshlegel FJ. Zinc deficiency in sickle cell disease. Clin Chem. 1975;21:582–587
  4. Prasad AS, Cossack ZT. Zinc supplementation and growth in sickle cell disease. Ann Intern Med. 1984;100:367–371
  5. Prasad AS, Abbasi AA, Rabbani P, DuMouchelle E. Effect of zinc supplementation on serum testosterone level in adult male sickle cell anemia subjects. Am J Hematol. 1981;10:119–127
  6. Warth JA, Prasad AS, Zwas F, Frank RN. Abnormal dark adaptation in sickle cell anemia. J Lab Clin Med. 1981;98:189–194
  7. Ballester OF, Abdallah JM, Prasad AS. Lymphocyte subpopulation abnormalities in sickle cell anemia. Am J Hematol. 1986;21:23–27
  8. Prasad AS, Meftah S, Abdallah J, et al. Serum thymulin in human zinc deficiency. J Clin Invest. 1988;82:1202–1210
  9. Niell HB, Leach BE, Kraus AP. Zinc metabolism in sickle cell anemia. JAMA. 1979;242:2686–2687
  10. Prasad AS, Ortega J, Brewer GJ, Oberleas D, Schoomaker EB. Trace elements in sickle cell disease. JAMA. 1976;235:2396–2398
  11. Tapazoglou E, Prasad A, Hill G, Brewer GJ, Kaplan J. Decreased natural killer cell activity in patients with zinc deficiency with sickle cell disease. J Lab Clin Med. 1985;105:11–22
  12. Beck FWJ, Kaplan J, Fine N, Handschu W, Prasad A. Decreased expression of CD73 (Ecto-5-nucleotidase) in the CD8+ subset is associated with zinc deficiency in humans. J Lab Clin Med. 1997;130:147–156
  13. Karayalcin G, Lanzkowsky P, Kazi AB. Zinc deficiency in children with sickle cell disease. Am J Pediatr Hematol Oncol. 1979;1:283–284
  14. Finan AC, Elmer MA, Sasanow SR, McKinney S, Russell MO, Gill FM. Nutritional factors and growth in children with sickle cell disease. Am J Dis Child. 1988;142:237–240
  15. Phebus CK, Maciak BJ, Gloninger MF, Paul HS. Zinc status of children with sickle cell disease: relationship to poor growth. Am J Hematol. 1988;29:67–73
  16. Prasad AS, Beck FW, Kaplan J, et al. Effect of zinc supplementation on incidence of infections and hospital admissions in sickle cell disease (SCD). Am J Hematol. 1999;61:194–202
  17. Raghupathy R, Haider MZ, Azizieh F, Abdelsalam R, D'Souza TM, Adekile AD. Th1 and Th2 cytokine profiles in sickle cell disease. Acta Haematol. 2000;103:197–202
  18. Yuzbasiyan-Gurkan VA, Brewer GJ, Vander AJ, Guenther MJ, Prasad A. Net renal tubular reabsorption of zinc in healthy man and impaired handling in sickle cell anemia. Am J Hematol. 1989;31:87–90
  19. Malave I, Perdomo Y, Escalona E, et al. Levels of tumor necrosis factor-α /cachectin (TNF alpha) in sera from patients with sickle cell disease. Acta Haematol. 1993;90:172–176
  20. Marwah SS, Blann AD, Rea C, Phillips JD, Wright J, Bareford D. Reduced vitamin E antioxidant capacity in sickle cell disease is related to transfusion status but not to sickle crisis. Am J Hematol. 2002;69:144–146
  21. Prasad AS, Bao B, Beck FW, Kucuk O, Sarkar FH. Antioxidant effect of zinc in humans. Free Radic Biol Med. 2004;37:1182–1190
  22. Prasad AS. Zinc: an overview. Nutrition. 1995;11:93–99
  23. Prasad AS, Beck FW, Bao B, et al. Zinc supplementation decreases incidence of infections in the elderly: effect of zinc on generation of cytokines and oxidative stress. Am J Clin Nutr. 2007;85:837–844
  24. Davis JN, Kucuk O, Djuric Z, Sarkar FH. Soy isoflavone supplementation in healthy men prevents NF-κB activation by TNF-α in blood lymphocytes. Free Radic Biol Med. 2001;30:1293–1302
  25. Prasad AS, Diwany M, Gabr M, Sandstead HH, Mokhtar N, Hefny AE. Biochemical studies in thalassemia. Ann Intern Med. 1965;62:87–96
  26. Dogru U, Arcasoy A, Cavdar AO. Zinc levels of plasma, erythrocyte, hair, and urine in homozygote beta thalassemia. Acta Haemat. 1979;62:41
  27. Arcsoy A, Cavdar AO, Erlug H, Gurpinar F. Zinc treatment in homozygous beta-Thalassemia (A preliminary study). In:  Prasad AS,  Cavdar AO,  Brewer GJ,  Aggett PJ editor. Zinc deficiency in human subjects. New York: Alan R. Liss; 1983;p. 107–116
  28. Moafi A, Mobaraki G, Taheri SS, Heidarzadeh A, Shahabi I, Majidi F. Zinc in thalassemic patients and its relation with depression. Biol Trace Elem Res. 2008;123:8–13
  29. Prasad AS, Fitzgerald J, Bao B, Beck FW, Chandrasekar PHl. Treatment of common cold with zinc acetate lozenges. Ann Int Med. 2000;133:245–252
  30. Shankar AH, Prasad AS. Zinc and immune function: the biological basis of altered resistance to infection. Am J Clin Nutr. 1998;68:447S–463S
  31. King LE, Frentzel JW, Mann JJ, Fraker PJ. Chronic zinc deficiency in mice disrupted T cell lymphopoiesis and erythropoiesis while B cell lymphopoiesis and myelopoiesis were maintained. J Am Coll Nutr. 2005;24:494–502
  32. Liew CW, Rand KD, Simpson RJ, et al. Molecular analysis of the interaction between the hematopoietic master transcription factors GATA-1 and PU.1. J Biol Chem. 2006;281:28296–28306
  33. Cantor AB, Orkin SH. Transcriptional regulation of erythropoiesis: an affair involving multiple partners. Oncogene. 2002;21:3368–3376
  34. Wessely O, Deiner EM, Beug H, von Lindern M. The glucocorticoid receptor is a key regulator of the decision between self-renewal and differentiation in erythroid progenitors. EMBO J. 1997;16:267–280
  35. von Lindern M, Zauner W, Mellitzer G, et al. The glucocorticoid receptor cooperates with the erythropoietin receptor and c-Kit to enhance and sustain proliferation of erythroid progenitors in vitro. Blood. 1999;94:550–559
  36. Leberbauer C, Boulmé F, Unfried G, Huber J, Beug H, Müllner EW. Different steroids co-regulate long-term expansion versus terminal differentiation in primary human erythroid progenitors. Blood. 2005;105:85–94
  37. Schnog JB, Lard LR, Rojer RA, Van der Dijs FP, Muskiet FA, Duits AJ. New concepts in assessing sickle cell disease severity. Am J Hematol. 1998;58:61–66
  38. Smolinski PA, Offermann MK, Eckman JR, Wick TM. Double-stranded RNA induces sickle erythrocyte adherence to endothelium: A potential role for viral infection in vaso-occlusive pain episodes in sickle cell anemia. Blood. 1995;85:2945–2950
  39. Hebbel RP, Vercellotti GM. The endothelial biology of sickle cell disease. J Lab Clin Med. 1997;129:288–293
  40. Solovey A, Gui L, Key NS, Hebbel RP. Tissue factor expression by endothelial cells in sickle cell anemia. J Clin Invest. 1998;101:1899–1904
  41. Kuvibidila SR, Sandoval M, Lao J, et al. Plasma zinc levels inversely correlate with vascular cell adhesion molecule-1 concentration in children with sickle cell disease. J Natl Med Assoc. 2006;98:1263–1272
  42. Wagner MC, Eckman JR, Wick TM. Sickle cell adhesion depends on hemodynamics and endothelial activation. J Lab Clin Med. 2004;144:260–267
  43. Castro L, Freeman BA. Reactive oxygen species in human health and disease. Nutrition. 2001;17:161–165
  44. Wood KC, Granger DN. Sickle cell disease: role of reactive oxygen and nitrogen metabolites. Clin Exp Pharmacol Physiol. 2007;34:926–932
  45. Ceylan E, Aksoy N, Gencer M, Vural H, Keles H, Selek S. Evaluation of oxidative-antioxidative status and the L-arginine-nitric oxide pathway in asthmatic patients. Respir Med. 2005;99:871–876
  46. Bettger WJ. Zinc and selenium, site-specific versus general antioxidant. Can. J. Physiol Pharmacol. 1993;71:721–724
  47. Hasanato RM. Zinc and antioxidant vitamin deficiency in patients with severe sickle cell anemia. Ann Saudi Med. 2006;26:17–21
  48. Lachance PA, Nakat Z, Jeong W. Antioxidants: an integrative approach. Nutrition. 2001;17:835–838
  49. Ozaki Y, Ohashi T, Kume S. Potentiation of neutrophil function by recombinant DNA-produced interleukin-1α. J Leukocyte Biol. 1987;42:621–627
  50. Berkow RL, Wang D, Larrick JW, Dodson RW, Howard TH. Enhancement of neutrophil superoxide production by pre-incubation with recombinant human tumor necrosis factor. J Immunol. 1987;139:3783–3791
  51. Prasad AS, Beck FW, Grabowski SM, Kaplan J. Zinc deficiency: changes in cytokine production and T-cell subpopulations in patients with head and neck cancer and in noncancer subjects. Proc Assoc Am Physicians. 1997;109:68–77
  52. Siebenlist U, Franzoso G, Brown K. Structure, regulation and function of NF-kappa B. Annu Rev Cell Biol. 1994;10:405–455
  53. Prasad AS, Brewer GJ, Schoonaker EB, Rabbani P. Hypocuprenuria induced by zinc therapy in adults. JAMA. 1978;240:2166–2168

 Supported by Grant 1-R01 A150698-01A1 from the National Institutes of Health (to A.P.) and by Grant FD-U-000457-06 from the Food and Drug Administration (to A.P.).

PII: S1931-5244(08)00157-6

doi: 10.1016/j.trsl.2008.06.001

Translational Research
Volume 152, Issue 2 , Pages 67-80 , August 2008