Translational Research
Volume 152, Issue 2 , Pages 95-98 , August 2008

Thrombospondin-1 and transforming growth factor beta are pro-inflammatory molecules in rheumatoid arthritis

Received 25 March 2008 ,Revised 5 June 2008 ,Accepted 19 June 2008.

References 

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  2. Koch AE, Szekanecz Z, Friedman J, Haines GK, Langman CB, Bouck NP. Effects of thrombospondin-1 on disease course and angiogenesis in rat adjuvant-induced arthritis. Clin Immunol Immunopathol. 1998;86:199–208
  3. Gotis-Graham I, Hogg PJ, McNeil HP. Significant correlation between thrombospondin 1 and serine proteinase expression in rheumatoid synovium. Arthritis Rheum. 1997;40:1780–1787
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  5. Pohlers D, Beyer A, Koczan D, Wilhelm T, Thiesen HJ, Kinne RW. Constitutive upregulation of the transforming growth factor-beta pathway in rheumatoid arthritis synovial fibroblasts. Arthritis Res Ther. 2007;9:R59
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  12. de Jager W, Hoppenreijs EP, Wulffraat NM, Wedderburn LR, Kuis W, Prakken BJ. Blood and synovial fluid cytokine signatures in patients with juvenile idiopathic arthritis: a cross-sectional study. Ann Rheum Dis. 2007;66:589–598
  13. Stuhlmuller B, Ungethum U, Scholze S, et al. Identification of known and novel genes in activated monocytes from patients with rheumatoid arthritis. Arthritis Rheum. 2000;43:775–790
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  15. Aggarwal A, Agarwal S, Misra R. Chemokine and chemokine receptor analysis reveals elevated interferon-inducible protein-10 (IP)-10/CXCL10 levels and increased number of CCR5+ and CXCR3+ CD4 T cells in synovial fluid of patients with enthesitis-related arthritis (ERA). Clin Exp Immunol. 2007;148:515–519
  16. Haas CS, Amin MA, Ruth JH, et al. In vivo inhibition of angiogenesis by interleukin-13 gene therapy in a rat model of rheumatoid arthritis. Arthritis Rheum. 2007;56:2535–2548

 Supported by Grant 1R24-MD001096-03 from the NIH, National Center of Minority Health and Health Disparities (to R.A.D.C.); by C000029889, DCED2729800, from the State of Pennsylvania (to R.A.D.C.); and by Supplement R01 Grant 3R01HL081322-02S1 from the NIH, National Heart and Blood Institute (to M.C.R.).

PII: S1931-5244(08)00169-2

doi: 10.1016/j.trsl.2008.06.002

Translational Research
Volume 152, Issue 2 , Pages 95-98 , August 2008

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