Translational Research
Volume 152, Issue 6 , Pages 265-272 , December 2008

Epidermal Growth Factor receptor (EGFR) regulates mechanical ventilation–induced lung injury in mice

Received 22 April 2008 ,Revised 1 October 2008 ,Accepted 3 October 2008.

References 

  1. Matthay MA, Zimmerman GA. Acute lung injury and the acute respiratory distress syndrome: four decades of inquiry into pathogenesis and rational management. Am J Respir Cell Mol Biol. 2005;33:319–327
  2. Waters CM. Reactive oxygen species in mechanotransduction. Am J Physiol Lung Cell Mol Physiol 200;287:L484–L485.
  3. Reddy SP, Hassoun PM, Brower R. Redox imbalance and ventilator-induced lung injury. Antioxid Redox Signal. 2007;9:2003–2012
  4. Belperio JA, Keane MP, Lynch JP, Strieter RM. The role of cytokines during the pathogenesis of ventilator-associated and ventilator-induced lung injury. Semin Respir Crit Care Med. 2006;27:350–364
  5. Fischer OM, Hart S, Gschwind A, Ullrich A. EGFR signal transactivation in cancer cells. Biochem Soc Trans. 2003;31:1203–1208
  6. Tschumperlin DJ, Shively JD, Swartz MA, Silverman ES, Haley KJ, Raab G, et al. Bronchial epithelial compression regulates MAP kinase signaling and HB-EGF-like growth factor expression. Am J Physiol Lung Cell Mol Physiol. 2002;282:L904–L911
  7. Tschumperlin DJ. EGFR autocrine signaling in a compliant interstitial space: mechanotransduction from the outside in. Cell Cycle. 2004;3:996–997
  8. Correa-Meyer E, Pesce L, Guerrero C, Sznajder JI. Cyclic stretch activates ERK1/2 via G proteins and EGFR in alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2002;282:L883–L891
  9. Papaiahgari S, Yerrapureddy A, Reddy SR, Reddy NM, Dodd-O JM, Crow MT, et al. Genetic and pharmacologic evidence links oxidative stressto ventilator-induced lung injury in mice. Am J Respir Crit Care Med. 2007;176:1222–1235
  10. Ma SF, Grigoryev DN, Taylor AD, Nonas S, Sammani S, Ye SQ, et al. Bioinformatic identification of novel early stress response genes in rodent models of lung injury. Am J Physiol Lung Cell Mol Physiol. 2005;289:L468–L477
  11. Wurfel MM. Microarray-based analysis of ventilator-induced lung injury. Proc Am Thorac Soc. 2007;4:77–84
  12. Halbertsma FJ, Vaneker M, Scheffer GJ, van der Hoeven JG. Cytokines and biotrauma in ventilator-induced lung injury: a critical review of the literature. Neth J Med. 2005;63:382–392
  13. Martin TR, Pistorese BP, Chi EY, Goodman RB, Matthay MA. Effects of leukotriene B4 in the human lung. Recruitment of neutrophils into the alveolar spaces without a change in protein permeability. J Clin Invest. 1989;84:1609–1619
  14. Papaiahgari S, Yerrapureddy A, Hassoun PM, Garcia JG, Birukov KG, Reddy SP. EGFR-activated signaling and actin remodeling regulate cyclic stretch-induced Nrf2-ARE activation. Am J Respir Cell Mol Biol. 2006;36:304–312
  15. Serhan CN, Chiang N, Van Dyke TE. Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators. Nat Rev Immunol. 2008;8:349–361
  16. Chu EK, Foley JS, Cheng J, Patel AS, Drazen JM, Tschumperlin DJ. Bronchial epithelial compression regulates epidermal growth factor receptor family ligand expression in an autocrine manner. Am J Respir Cell Mol Biol. 2005;32:373–380
  17. Grigoryev DN, Ma SF, Simon BA, Irizarry RA, Ye SQ, Garcia JG. In vitro identification and in silico utilization of interspecies sequence similarities using GeneChip technology. BMC Genomics. 2005;6:62
  18. Hai T, Wolfgang CD, Marsee DK, Allen AE, Sivaprasad U. ATF3 and stress responses. Gene Expr. 1999;7:321–335

 Supported by NIH grants SCCOR P50 HL073994 (to S.P.R. and P.H.), HL66109 (to S.P.R.), and HL049441 (to P.H.).

PII: S1931-5244(08)00243-0

doi: 10.1016/j.trsl.2008.10.004

Translational Research
Volume 152, Issue 6 , Pages 265-272 , December 2008

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