Translational Research
Volume 154, Issue 1 , Pages 34-39 , July 2009

Early evaluation of acute traumatic coagulopathy by thrombelastography

  • Roger C. Carroll

      Affiliations

    • Department of Anesthesiology, University of Tennessee Graduate School of Medicine, Knoxville, Tenn
    • Corresponding Author InformationReprint requests: Roger C. Carroll, PhD, Department of Anesthesiology, University of Tennessee Graduate School of Medicine, 1924 Alcoa Highway, Knoxville, TN; 37920
    • ,
  • Robert M. Craft

      Affiliations

    • Department of Anesthesiology, University of Tennessee Graduate School of Medicine, Knoxville, Tenn
    • ,
  • Russell J. Langdon

      Affiliations

    • Department of Anesthesiology, University of Tennessee Graduate School of Medicine, Knoxville, Tenn
    • ,
  • Colin R. Clanton

      Affiliations

    • Department of Anesthesiology, University of Tennessee Graduate School of Medicine, Knoxville, Tenn
    • ,
  • Carolyn C. Snider

      Affiliations

    • Department of Anesthesiology, University of Tennessee Graduate School of Medicine, Knoxville, Tenn
    • ,
  • Douglas D. Wellons

      Affiliations

    • Department of Anesthesiology, University of Tennessee Graduate School of Medicine, Knoxville, Tenn
    • ,
  • Patrick A. Dakin

      Affiliations

    • Department of Anesthesiology, University of Tennessee Graduate School of Medicine, Knoxville, Tenn
    • ,
  • Christy M. Lawson

      Affiliations

    • Department of Surgery, University of Tennessee Graduate School of Medicine, Knoxville, Tenn
    • ,
  • Blaine L. Enderson

      Affiliations

    • Department of Surgery, University of Tennessee Graduate School of Medicine, Knoxville, Tenn
    • ,
  • Stanley J. Kurek

      Affiliations

    • Department of Surgery, University of Tennessee Graduate School of Medicine, Knoxville, Tenn

Received 17 November 2008 ,Revised 2 April 2009 ,Accepted 3 April 2009.

References 

  1. MacLeod JB, Lynn M, McKenney MG, Cohn SM, Murtha M. Early coagulopathy predicts mortality in trauma. J Trauma. 2003;55:39–44
  2. Brohi K, Cohen MJ, Ganter MT, Matthay MA, Mackersie RC, Pittet JF. Acute traumatic coagulopathy: initiated by hypoperfusion: modulated through the protein C pathway?. Ann Surg. 2007;245:812–818
  3. Brohi K, Singh J, Heron M, Coats T. Acute traumatic coagulopathy. J Trauma. 2003;54:1127–1130
  4. Brohi K, Cohen MJ, Davenport RA. Acute coagulopathy of trauma: mechanism, identification and effect. Curr Opin Crit Care. 2007;13:680–685
  5. Hess JR, Brohi K, Dutton RP, et al. The coagulopathy of trauma: a review of mechanisms. J Trauma. 2008;65:748–754
  6. Brohi K, Cohen MJ, Ganter MT, et al. Acute coagulopathy of trauma: hypoperfusion induces systemic anticoagulation and hyperfibrinolysis. J Trauma. 2008;64:1211–1217
  7. Jacoby RC, Owings JT, Holmes J, Battistella FD, Gosselin RC, Paglieroni TG. Platelet activation and function after trauma. J Trauma. 2001;51:639–647
  8. Nekludov M, Bellander BM, Blomback M, Wallen HN. Platelet dysfunction in patients with severe traumatic brain injury. J Neurotrauma. 2007;24:1699–1706
  9. Plotkin AJ, Wade CE, Jenkins DH, et al. A reduction in clot formation rate and strength assessed by thrombelastography is indicative of transfusion requirements in patients with penetrating injuries. J Trauma. 2008;64:S64–S68
  10. Maegele M, Lefering R, Yucel N, et al. Early coagulopathy in multiple injury: an analysis from the German Trauma Registry on 8724 patients. Injury. 2007;38:298–304
  11. Anderson L, Quasim I, Soutar R, Steven M, Macfie A, Korte W. An audit of red cell and blood product use after the institution of thromboelastometry in a cardiac intensive care unit. Transfus Med. 2006;16:31–39
  12. Avidan MS, Alcock EL, Da FJ, et al. Comparison of structured use of routine laboratory tests or near-patient assessment with clinical judgement in the management of bleeding after cardiac surgery. Br J Anaesth. 2004;92:178–186
  13. Shore-Lesserson L, Manspeizer HE, DePerio M, Francis S, Vela-Cantos F, Ergin MA. Thromboelastography-guided transfusion algorithm reduces transfusions in complex cardiac surgery. Anesth Analg. 1999;88:312–319
  14. Gillies BS. Thromboelastography and liver transplantation. Semin Thromb Hemost. 1995;21:45–49
  15. Kang Y. Coagulation and liver transplantation. Transplant Proc. 1993;25:2001–2005
  16. Kang YG, Martin DJ, Marquez J, et al. Intraoperative changes in blood coagulation and thrombelastographic monitoring in liver transplantation. Anesth Analg. 1985;64:888–896
  17. Levrat A, Gros A, Rugeri L, et al. Evaluation of rotation thrombelastography for the diagnosis of hyperfibrinolysis in trauma patients. Br J Anaesth. 2008;100:792–797
  18. Rugeri L, Levrat A, David JS, et al. Diagnosis of early coagulation abnormalities in trauma patients by rotation thrombelastography. J Thromb Haemost. 2007;5:289–295
  19. Kaufmann CR, Dwyer KM, Crews JD, Dols SJ, Trask AL. Usefulness of thrombelastography in assessment of trauma patient coagulation. J Trauma. 1997;42:716–720
  20. Avikainen V. Coagulation disorders in severely and critically injured patients. Ann Chir Gynaecol. 1977;66:269–277
  21. Carroll RC, Craft RM, Chavez JJ, Snider CC, Bresee SJ, Cohen EA. Thrombelastograph whole blood assay for clinical monitoring of NSAID-insensitive transcellular platelet activation by arachidonic acid. J Lab Clin Med. 2005;146:30–35
  22. Craft RM, Chavez JJ, Bresee SJ, Wortham DC, Cohen E, Carroll RC. A novel modification of the Thrombelastograph assay, isolating platelet function, correlates with optical platelet aggregation. J Lab Clin Med. 2004;143:301–309
  23. Craft RM, Chavez JJ, Snider CC, Muenchen RA, Carroll RC. Comparison of modified Thrombelastograph and Plateletworks whole blood assays to optical platelet aggregation for monitoring reversal of clopidogrel inhibition in elective surgery patients. J Lab Clin Med. 2005;145:309–315
  24. Ganter MT, Hofer CK. Coagulation monitoring: current techniques and clinical use of viscoelastic point-of-care coagulation devices. Anesth Analg. 2008;106:1366–1375
  25. Carroll RC, Craft RM, Chavez JJ, Snider CC, Kirby RK, Cohen E. Measurement of functional fibrinogen levels using the Thrombelastograph. J Clin Anesth. 2008;20:186–190

 Supported by Haemoscope Corporation, and 1 author (R.C.C.) is a paid consultant for Haemoscope Corporation.

PII: S1931-5244(09)00113-3

doi: 10.1016/j.trsl.2009.04.001

Translational Research
Volume 154, Issue 1 , Pages 34-39 , July 2009

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