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Translational Research
Volume 154, Issue 4
, Pages 165-174
, October 2009
Targeting the airway smooth muscle for asthma treatment
References
- . Development of the innervation and airway smooth muscle in human fetal lung. Am J Respir Cell Mol Biol. 1999;20:550–560
- . Stretch-induced alternative splicing of serum response factor promotes bronchial myogenesis and is defective in lung hypoplasia. J Clin Invest. 2000;106:1321–1330
- . Point: airway smooth muscle is useful. J Appl Physiol. 2007;102:1708–1709
- . Airway smooth muscle: the appendix of the lung. Am J Respir Crit Care Med. 2004;169:787–790
- . Cellular hypertrophy and hyperplasia of airway smooth muscles underlying bronchial asthma: a 3-D morphometric study. Am Rev Respir Dis. 1993;148:720–726
- Hyperplasia of smooth muscle in mild to moderate asthma without changes in cell size or gene expression. Am J Respir Crit Care Med. 2004;169:1001–1006
- . Airway smooth muscle in asthma. Ann Rev Pathol Mech Dis. 2008;3:523–555
- . Structural changes in the airways in asthma: observations and consequences. Clin Sci. 2005;108:463–477
- Abnormal growth of smooth muscle-like cells in lymphangioleiomyomatosis: role for tumor suppressor TSC2. Am J Respir Cell Mol Biol. 2006;34:561–572
- . Combined smooth muscle and melanocytic differentiation in lymphangioleiomyomatosis. J Histochem Cytochem. 2004;52:1537–1542
- . Transforming growth factor-ß1 and extracellular matrix-associated fibronectin expression in pulmonary lymphangioleiomyomatosis. Chest. 2004;125:1063–1070
- . Smooth muscle-like cells in pulmonary lymphangioleiomyomatosis. Proc Am Thorac Soc. 2008;5:119–126
- . Lymphangioleiomyomatosis: a review. Eur J Int Med. 2008;19:319–324
- . The role of airway smooth muscle in the pathogenesis of airway wall remodeling in chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2005;2:347–354
- . Peripheral airway smooth muscle mechanics in obstructive airways disease. Am J Respir Crit Care Med. 2000;161:910–917
- Airway smooth muscle dynamics: a common pathway of airway obstruction in asthma. Eur Respir J. 2007;29:834–860
- Airway smooth muscle in bronchial tone, inflammation, and remodeling: basic knowledge to clinical relevance. Am J Respir Crit Care Med. 2008;177:248–252
- . Antileukotriene drugs: clinical application, effectiveness and safety. Curr Med Chem. 2007;14:1966–1977
- . Omalizumab for asthma. N Engl J Med. 2006;354:2689–2695
- . Stem cells in airway smooth muscle: state of the art. Proc Am Thorac Soc. 2008;5:11–14
- Airway smooth muscle cell proliferation is increased in asthma. Am J Respir Crit Care Med. 2001;164:474–477
- . Translational regulation of gene expression by {omega}-3 fatty acids. J Nutr. 2004;134:2487S–2491S
- . Migration of airway smooth muscle cells. Proc Am Thorac Soc. 2008;5:97–105
- . Retinoic acid inhibits airway smooth muscle cell migration. Am J Respir Cell Mol Biol. 2006;34:695–703
- Statins effect on smooth muscle cell proliferation. Semin Vasc Med. 2004;4:347–356
- . The effect of six different statins on the proliferation, migration, and invasion of human smooth muscle cells. J Surg Res. 2005;129:52–56
- . Role of RhoA inactivation in reduced cell proliferation of human airway smooth muscle by simvastatin. Am J Respir Cell Mol Biol. 2006;35:722–729
- Measurement in vivo of proliferation rates of slow turnover cells by 2H2O labeling of the deoxyribose moiety of DNA. Proc Nat Acad Sci USA. 2002;99:15345–15350
- . Measurement of mouse vascular smooth muscle and atheroma cell proliferation by 2H2O incorporation into DNA. Am J Physiol Cell Physiol. 2006;291:C1014–C1021
- . Induction of human airway smooth muscle apoptosis by neutrophils and neutrophil elastase. Am J Respir Cell Mol Biol. 2005;32:334–341
- Effects of decorin and biglycan on human airway smooth muscle cell proliferation and apoptosis. Am J Physiol Lung Cell Mol Physiol. 2008;294:L764–L771
- Airway proteoglycans are differentially altered in fatal asthma. J Pathol. 2005;207:102–110
- Fas cross-linking induces apoptosis in human airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2000;278:L618–L624
- . Inhibitors of HMG-CoA reductase sensitize human smooth muscle cells to Fas-ligand and cytokine-induced cell death. Atherosclerosis. 2000;152:217–227
- Shimizu K, Sugiyama S, Aikawa M, et al. Host bone-marrow cells are a source of donor intimal smooth- muscle-like cells in murine aortic transplant arteriopathy. 2001;7:738–741.
- . Identification of circulating fibrocytes as precursors of bronchial myofibroblasts in asthma. J Immunol. 2003;171:380–389
- . Tissue fibrocytes in patients with mild asthma: a possible link to thickness of reticular basement membrane?. Respir Res. 2006;7:50
- Increased circulating fibrocytes in asthma with chronic airflow obstruction. Am J Respir Crit Care Med. 2008;178:583–591
- . Isolation of an adult mouse lung mesenchymal progenitor cell population. Am J Respir Cell Mol Biol. 2007;37:152–159
- . Embryonic lung side population cells are hematopoietic and vascular precursors. Am J Respir Cell Mol Biol. 2005;33:32–40
- Evidence for tissue-resident mesenchymal stem cells in human adult lung from studies of transplanted allografts. J Clin Invest. 2007;117:989–996
- . Epithelial-mesenchymal communication in the pathogenesis of chronic asthma. Proc Am Thorac Soc. 2004;1:93–98
- . TGF-ß1 induces human alveolar epithelial to mesenchymal cell transition (EMT). Respir Res. 2005;6:56
- Detection of epithelial to mesenchymal transition in airways of a bleomycin induced pulmonary fibrosis model derived from an alpha-smooth muscle actin-Cre transgenic mouse. Respir Res. 2007;8:1
- Dong L, Wang S, Li H. Role of FIZZ1 in airway remodeling of OVA-induced asthma. J Asthma. In press.
- . Transforming growth factor-beta1 and disorders of the lung. Cell Biochem Biophys. 2005;43:131–148
- . Epithelial origin of myofibroblasts during fibrosis in the lung. Proc Am Thorac Soc. 2006;3:377–382
- Proteinase-activated receptor 4 stimulation-induced epithelial-mesenchymal transition in alveolar epithelial cells. Respir Res. 2007;8:31
- Dual-immunohistochemistry provides little evidence for epithelial–mesenchymal transition in pulmonary fibrosis. Histochem Cell Biol. 2008;129:453–462
- . New targets for drug development in asthma. Lancet. 2008;372:1073–1087
- . Treating asthma means treating airway smooth muscle cells. Eur Respir J. 2008;32:265–274
- . Radiofrequency ablation of airway smooth muscle for sustained treatment of asthma: preliminary investigations. Eur Respir J. 2004;24:659–663
- Asthma control during the year after bronchial thermoplasty. N Engl J Med. 2007;356:1327–1337
- Reduction in mild exacerbations rates and improvement in asthma status following bronchial thermoplasty. Chest. 2006;130:109S
- . A prospective feasibility study of bronchial thermoplasty in the human airway. Chest. 2005;127:1999–2006
- . Phenotype and functional plasticity of airway smooth muscle: role of caveolae and caveolins. Proc Am Thorac Soc. 2008;5:80–88
- . Rho and vascular disease. Atherosclerosis. 2005;183:1–16
- . Comparison of the efficacies of five different statins on inhibition of human saphenous vein smooth muscle cell proliferation and invasion. J Cardiovasc Pharmacol. 2007;50:458–461
- Efficacy and tolerability of lovastatin in 3390 women with moderate hypercholesterolemia. Ann Intern Med. 1993;118:850–855
- Attenuation of chronic hypoxic pulmonary hypertension by simvastatin. Am J Physiol Heart Circ Physiol. 2003;285:H938–H945
- Simvastatin rescues rats from fatal pulmonary hypertension by inducing apoptosis of neointimal smooth muscle cells. Circulation. 2003;108:1640–1645
- Regression of chronic hypoxic pulmonary hypertension by simvastatin. Am J Physiol Lung Cell Mol Physiol. 2007;292:L1105–L1110
- . A novel anti-inflammatory role of simvastatin in a murine model of allergic asthma. J Immunol. 2004;172:2903–2908
- . Potential therapeutic role for statins in respiratory disease. Thorax. 2006;61:729–734
- . The role of the mast cell in the pathophysiology of asthma. J Allergy Clin Immunol. 2006;117:1277–1284
- Mast cells promote airway smooth muscle cell differentiation via autocrine up-regulation of TGF-{beta}1. J Immunol. 2008;181:5001–5007
- Human airway smooth muscle promotes human lung mast cell survival, proliferation, and constitutive activation: Cooperative roles for CADM1, stem cell factor, and IL-6. J Immunol. 2008;181:2772–2780
- HMG-CoA reductase inhibitor simvastatin inhibits proinflammatory cytokine production from murine mast cells. Int Arch Allergy Immunol. 2008;146:61–66
- Effects of various statins on cytokine-dependent growth and IgE-dependent release of histamine in human mast cells. Allergy. 2006;61:281–288
- . Simvastatin treatment of pulmonary hypertension: an observational case series. Chest. 2005;127:1446–1452
- . The use of statins and lung function in current and former smokers. Chest. 2007;132:1764–1771
- . Statins may reduce episodes of exacerbation and the requirement for intubation in patients with COPD: evidence from a retrospective cohort study. Intl J Clin Pract. 2008;62:1373–1378
- Prior statin therapy is associated with a decreased rate of severe sepsis. Circulation. 2004;110:880–885
- . Statin use is associated with reduced mortality in COPD. Eur Respir J. 2007;29:279–283
- . Influenza and COPD mortality protection as pleiotropic, dose-dependent effects of statins. Chest. 2007;131:1006–1012
- . Simvastatin does not exhibit therapeutic anti-inflammatory effects in asthma. J Allergy Clin Immunol. 2007;119:328–335
- Effects of atorvastatin added to inhaled corticosteroids on lung function and sputum cell counts in atopic asthma. Thorax. 2008;63:1070–1075
- An HMG-CoA reductase inhibitor, cerivastatin, suppresses growth of macrophages expressing matrix metalloproteinases and tissue factor in vivo and in vitro. Circulation. 2001;103:276–283
- Statin exposure reduces the risk of asthma-related hospitalizations and emergency room visits in asthmatic patients on inhaled corticosteroids. J Allergy Clin Immunol. 2009;123:S65
- Lovastatin inhibits the development of airway hyperresponsiveness and remodeling induced by chronic TGF-beta exposure. Am J Crit Care Med. 2007;175:A162
- Statin inhibit serum response factor (SRF)-dependent gene expression in airway smooth muscle cells. Am J Crit Care Med. 2002;165:A779
- . An assessment of statin safety by muscle experts. Am J Cardiol Report of the National Lipid Association's Statin Safety Task Force. 2006;97:S69–S76
- . SLCO1B1 variants and statin-induced myopathy—A genomewide study. N Engl J Med. 2008;359:789–799
- A Therapeutic dose of the lipophilic statin pitavastatin enhances oxidant-induced apoptosis in human vascular smooth muscle cells. J Cardiovasc Pharmacol. 2006;48:160–165
- Rosuvastatin regulates vascular smooth muscle cell phenotypic modulation in vascular remodeling: role for the urokinase receptor. Atherosclerosis. 2007;195:254–261
- . Upregulation of angiotensin II-AT1 receptors during statin withdrawal in vascular smooth muscle cells. J Cardiovas Pharmacol. 2007;50:708–711
- . Statin withdrawal: clinical implications and molecular mechanisms. Pharmacotherapy. 2006;26:1288–1296
- The Effects of HMG-CoA reductase inhibitor on vascular progenitor cells. J Pharmacol Sci. 2006;101:344–349
- . Simvastatin suppresses self-renewal of mouse embryonic stem cells by inhibiting RhoA geranylgeranylation. Stem Cells. 2007;25:1654–1663
- . Pharmacogenomics of statin responsiveness. Am J Cardiol. 2005;96:65–70
- . Novel therapies for children with severe asthma. Curr Opini Pediatr. 2008;20:261–265
Supported by grants K01HL092588 and CTSA UL1 RR024999 and by the ALA and Blowitz-Ridge Foundation, the American Thoracic Society, and the LAM Foundation.
PII: S1931-5244(09)00184-4
doi: 10.1016/j.trsl.2009.06.008
© 2009 Mosby, Inc. All rights reserved.
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Translational Research
Volume 154, Issue 4
, Pages 165-174
, October 2009
