Translational Research
Volume 154, Issue 4 , Pages 214-218 , October 2009

Cerebrospinal fluid lactate dehydrogenase isoenzymes in children with bacterial and aseptic meningitis

  • Moshe Nussinovitch

      Affiliations

    • Department of Pediatrics C, Schneider Children's Medical Center of Israel, Petach Tikva, Israel
    • Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    • Corresponding Author InformationReprint requests: Moshe Nussinovitch, Department of Pediatrics C, Schneider Children's Medical Center of Israel, Petach Tikva, Israel 49202
    • ,
  • Yaron Finkelstein

      Affiliations

    • Divisions of Clinical Pharmacology and Toxicology and Emergency Medicine, Department of Pediatrics, Hospital for Sick Children, Ontario, Canada
    • ,
  • Keren Politi Elishkevitz

      Affiliations

    • Department of Pediatrics B, Schneider Children's Medical Center of Israel, Petach Tikva, Israel
    • Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    • ,
  • Benjamin Volovitz

      Affiliations

    • Department of Pediatrics C, Schneider Children's Medical Center of Israel, Petach Tikva, Israel
    • Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    • ,
  • Daniella Harel

      Affiliations

    • Laboratory of Clinical Chemistry, Rabin Medical Center, Beilinson Campus, Petach Tikva, Israel
    • Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    • ,
  • Gil Klinger

      Affiliations

    • Department of Neonatal Intensive Care, Schneider Children's Medical Center of Israel, Petach Tikvah, Israel
    • Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    • ,
  • Yaron Razon

      Affiliations

    • Cardiac Intensive Care Unit, Schneider Children's Medical Center of Israel, Petach Tikvah, Israel
    • Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    • ,
  • Udi Nussinovitch

      Affiliations

    • Department of Internal Medicine B, Chaim Sheba Medical Center, Tel Hashomer, Israel
    • Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    • ,
  • Naomi Nussinovitch

      Affiliations

    • Hypertension Unit and Department of Internal Medicine D, Chaim Sheba Medical Center, Tel Hashomer, Israel
    • Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

Received 2 May 2009 ,Revised 12 June 2009 ,Accepted 27 June 2009.

References 

  1. Scarborough M, Thwaites GE. The diagnosis and management of acute bacterial meningitis in resource-poor settings. Lancet Neurol. 2008;7:637–648
  2. Neches W, Platt M. Cerebrospinal fluid LDH in 287 children, including 53 cases of meningitis of bacterial and non-bacterial etiology. Pediatrics. 1968;41:1097–1103
  3. Kamat DV, Chakravorty BP. Comparative values of CSF-LDH isoenzymes in neurological disorders. Indian J Med Sci. 1999;53:1–6
  4. Feldman WE. Cerebrospinal fluid lactic acid dehydrogenase activity. Levels in untreated and partially antibiotic-treated meningitis. Am J Dis Child. 1975;129:77–80
  5. Nussinovitch M, Avitzur Y, Finkelstein Y, Amir J, Harel D, Volovitz B. Lactic dehydrogenase isoenzyme in cerebrospinal fluid of children with febrile convulsions. Acta Paediatr. 2003;92:186–189
  6. Nussinovitch M, Harel D, Eidlitz-Markus T, Amir J, Volovitz B. Lactic dehydrogenase isoenzyme in cerebrospinal fluid of children with infantile spasms. Eur Neurol. 2003;49:231–233
  7. Nussinovitch M, Prais D, Finkelstein Y, Harel D, Amir J, Volovitz B. Lactic dehydrogenase isoenzymes in cerebrospinal fluid of children with Guillain-Barre syndrome. Arch Dis Child. 2002;87:255–256
  8. Nussinovitch M, Volovitz B, Finkelstein Y, Amir J, Harel D. Lactic dehydrogenase isoenzymes in cerebrospinal fluid associated with hydrocephalus. Acta Paediatr. 2001;90:972–974
  9. Landaas S, Von der Lippe B. Chemical analyses for early differential diagnosis between bacterial and viral meningitis. Scand J Clin Lab Invest. 1985;45:525–529
  10. Donald PR, Malan C. Cerebrospinal fluid lactate and lactate dehydrogenase activity in the rapid diagnosis of bacterial meningitis. S Afr Med J. 1986;69:39–42
  11. Nelson PV, Carey WF, Pollard AC. Diagnostic significance and source of lactate dehydrogenase and its isoenzymes in cerebrospinal fluid of children with a variety of neurological disorders. J Clin Pathol. 1975;28:828–833
  12. Lutsar I, Haldre S, Topman M, Talvik T. Enzymatic changes in the cerebrospinal fluid in patients with infections of the central nervous system. Acta Paediatr. 1994;83:1146–1150
  13. Tapiainen T, Prevots R, Izurieta HS, et al. Aseptic meningitis: case definition and guidelines for collection, analysis and presentation of immunization safety data. Vaccine. 2007;25:5793–5802
  14. Prober CG. Central nervous system infections. In:  Behrman RE,  Kliegman RM,  Jenson HB editor. Nelson Textbook of Pediatrics. 16th ed.. Philadelphia, PA: WB Saunders; 1999;p. 751–757
  15. Nussinovitch M, Klinger G, Soen G, et al. Increased creatine kinase brain isoenzyme concentration in cerebrospinal fluid with meningitis. Clin Pediatr. 1996;35:349–351
  16. Beaty HN, Oppenheimer S. Cerebrospinal-fluid lactic dehydrogenase and its isoenzymes in infections of the central nervous system. N Engl J Med. 1968;279:1197–1202
  17. Wroblewski F. The mechanisms of alteration in lactic dehydrogenase activity of body fluids. Ann NY Acad Sci. 1958;75:322–338
  18. Van Der Helm HJ, Zondag HA, Klein F. On the source of lactic dehydrogenase in cerebrospinal fluid. Clin Chim Acta. 1963;8:193–196
  19. Feldman WE. Concentrations of bacteria in cerebrospinal fluid of patients with bacterial meningitis. J Pediatr. 1976;88:549–552
  20. Nussinovitch M, Prais D, Volovitz B, Amir J, Harel D, Nussinovitch A. Reference values for lactic dehydrogenase activity and isoenzyme distribution in cerebrospinal fluid in neonates with fever but no evidence of cerebral disease. Am J Perinatol. 2002;19:109–114
  21. Hall RT, Kulkarni PB, Sheehan MB, Rhodes PG. Cerebrospinal fluid lactate dehydrogenase in infants with perinatal asphyxia. Dev Med Child Neurol. 1980;22:300–307

 U. and N. Nussinovitch contributed equally to this article.

PII: S1931-5244(09)00213-8

doi: 10.1016/j.trsl.2009.06.011

Translational Research
Volume 154, Issue 4 , Pages 214-218 , October 2009

Article Tools