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Translational Research
Volume 154, Issue 4
, Pages 161-164
, October 2009
Genome-wide association studies: hypothesis-“free” or “engaged”?
References
- . Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease. Nat Genet. 2003;33:177–182
- . Genome-wide association studies for common diseases and complex traits. Nat Rev Genet. 2005;6:95–108
- . From Darwin's finches to canaries in the coal mine—mining the genome for new biology. N Engl J Med. 2008;358:2760–2763
- . How to interpret a genome-wide association study. JAMA. 2008;299:1335–1344
- . A HapMap harvest of insights into the genetics of common disease. J Clin Invest. 2008;118:1590–1605
- . Common genetic variation and human traits. N Engl J Med. 2009;360:1696–1698
- . Genetic risk prediction—are we there yet?. N Engl J Med. 2009;360:1701–1703
- Genome-wide association studies for complex traits: consensus, uncertainty and challenges. Nat Rev Genet. 2008;9:356–369
- . Genomewide association studies and human disease. N Engl J Med. 2009;360:1759–1768
- . Genome-wide association studies: potential next steps on a genetic journey. Hum Mol Genet. 2008;17:R156–R165
- . On the allelic spectrum of human disease. Trends Genet. 2001;17:502–510
- . The genetic basis of complex traits: rare variants or “common gene, common disease”?. Methods Mol Biol. 2007;376:71–84
- . Methods for detecting associations with rare variants for common diseases: application to analysis of sequence data. Am J Hum Genet. 2008;83:311–321
- . Common and rare variants in multifactorial susceptibility to common diseases. Nat Genet. 2008;40:695–701
- . Multiple rare alleles contribute to low plasma levels of HDL cholesterol. Science. 2004;305:869–872
- Rare independent mutations in renal salt handling genes contribute to blood pressure variation. Nat Genet. 2008;40:592–599
- 1000 Genomes Project: http://www.1000genomes.org.
- . Copy number variants and common disorders: filling the gaps and exploring complexity in genome-wide association studies. PLoS Genet. 2007;3:1787–1799
- Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease. Nat Genet. 2008;40:1107–1112
- Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet. 2009;41:25–34
- . Copy-number variation and association studies of human disease. Nat Genet. 2007;39:S37–S42
- Integrated detection and population-genetic analysis of SNPs and copy number variation. Nat Genet. 2008;40:1166–1174
- . Future impact of integrated high-throughput methylome analyses on human health and disease. J Genet Genomics. 2008;35:391–401
- . The genetic signatures of noncoding RNAs. PLoS Genet. 2009;5:e1000459
- . Epistasis: what it means, what it doesn't mean, and statistical methods to detect it in humans. Hum Mol Genet. 2002;11:2463–2468
- . Genome-wide association studies: detecting gene-gene interactions that underlie human diseases. Nat Rev Genet. 2009;[Epub ahead of print]
- Expectations and challenges stemming from genome-wide association studies. Mutagenesis. 2008;23:439–444
- . Gene-environment interaction in genome-wide association studies. Am J Epidemiol. 2009;169:219–226
- Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. Proc Natl Acad Sci U S A. 2009;106:9362–9367
- . Genetic dissection of diseases: design and methods. Curr Opin Genet Dev. 2004;14:229–232
- . The hypothesis is there is no hypothesis. The Microarray Meeting, Scottsdale, Arizona, USA, 22-25 September 1999. Trends Genet. 2000;16:63–64
- . Hypothesis-free? No such thing. The Scientist. 2008;22:31
Supported by the National Institutes of Health/National Center for Research Resources (UL1 RR025752).
PII: S1931-5244(09)00214-X
doi: 10.1016/j.trsl.2009.07.001
© 2009 Mosby, Inc. All rights reserved.
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Translational Research
Volume 154, Issue 4
, Pages 161-164
, October 2009
