« Previous
Next »
Translational Research
Volume 154, Issue 4
, Pages 202-213
, October 2009
Iron sufficient to cause hepatic fibrosis and ascites does not cause cardiac arrhythmias in the gerbil
References
- . Hereditary iron overload: update on pathophysiology, diagnosis, and treatment. Am J Hematol. 2006;81:202–209
- . Thalassemias and related disorders: quantitative disorders of hemoglobin synthesis. In: Greer JP, Foerster J, Lukens JN, Rodgers GM, Paraskevas F, Glader BE editor. Wintrobe's clinical hematology. 11th ed. Philadelphia, Pa: Williams & Wilkins: Lippincott; 2004;
- Survival and disease complications in thalassemia major. Ann NY Acad Sci. 1998;850:227–230
- . Cardiac involvement in Cooley's anemia. Ann NY Acad Sci. 1964;119:694–702
- . Late cardiac complications of chronic, severe, refractory anemia with hemochromatosis. Circulation. 1964;30:698–705
- . Transfusion-dependent thalassaemia: a new era. Med J Aust. 2008;188:68–69
- . Survival in β-thalassemia major in the UK: data from the UK Thalassaemia Register. Lancet. 2000;355:2051–2052
- . Survival and desferrioxamine in thalassaemia major. Br Med J. 1982;284:1081–1084
- Longitudinal study of cardiac function in thalassemia major. Ann NY Acad Sci. 1980;344:397–404
- Disease-related conditions in relatives of patients with hemochromatosis. N Engl J Med. 2000;343:1529–1535
- Cardiac involvement in thalassemia intermedia: a multicenter study. Blood. 2001;97:3411–3416
- . Long-term outcome of continuous 24-hour deferoxamine infusion via indwelling intravenous catheters in high-risk beta-thalassemia. Blood. 2000;95:1229–1236
- . Cardiac arrhythmias in thalassaemia major: evaluation of chelation therapy using ambulatory monitoring. Br Med J. 1978;1:342
- Improved survival of thalassaemia major in the UK and relation to T2∗ cardiovascular magnetic resonance. J Cardiovasc Magn Reson. 2008;10:42–49
- . A unique rodent model for both the cardiotoxic and hepatotoxic effects of prolonged iron overload. Lab Invest. 1993;69:217–222
- Deferoxamine promotes survival and prevents electrocardiographic abnormalities in the gerbil model of iron-overload. J Lab Clin Med. 2003;141:121–130
- Iron does not cause arrhythmias in the guinea pig model of transfusional iron overload. Comp Med. 2007;57:383–389
- Bimodal cardiac dysfunction in an animal model of iron overload. J Lab Clin Med. 2002;140:263–271
- Deferoxamine prevents cardiac hypertrophy and failure in the gerbil model of iron-induced cardiomyopathy. J Lab Clin Med. 2003;142:332–340
- . Measurement of heart rate and Q-T interval in the conscious mouse. Am J Physiol. 1998;274:H747–H51
- . 2004. In vivo temporal and spatial distribution of depolarization and repolarization and the illusive murine T wave. J Physiol. 2004;555:267–279
- . Electrocardiogram and phonogram of adult and newborn mice in normal conditions and under the effect of cooling, hypoxia and potassium. Am J Physiol. 1953;174:293–298
- . Modulation of biological function of galectin-3 by matrix metalloproteinases. Biochim Biophys Acta. 1998;1379:97–106
- Survival and causes of death in thalassaemia major. Lancet. 1998;2:27–31
- . Iron in the heart: etiology and clinical significance. Am J Med. 1971;51:209–221
- . Reversal of cardiac complications in thalassemia major by long-term intermittent daily intensive iron chelation. Eur J Haematol. 2003;70:398–403
- . Cardiac arrhythmias: From (transgenic) mice to men. J Cardiovasc Electrophysiol. 2001;12:1089–1091
- . Age and anesthetic effects on murine electrocardiography. Life Sci. 2003;72:2401–2412
- Acetaminophen protects against iron-induced cardiac damage in gerbils. Ann Clin Lab Sci. 2007;37:22–33
- Deferasirox and deferiprone remove cardiac iron in the iron-overloaded gerbil. Transl Res. 2006;48:272–280
- . The iron-loaded gerbil model revisited: effects of deferoxamine and deferiprone treatment. J Lab Clin Med. 2002;139:50–58
- Galectin-3 expression and secretion links macrophages to the promotion of renal fibrosis. Am J Pathol. 2008;172:288–298
- Galectin-3 marks activated macrophages in failure-prone hypertrophied hearts and contributes to cardiac dysfunction. Circulation. 2004;110:3121–3128
- Galectin-3 regulates myofibroblast activation and hepatic fibrosis. Proc Natl Acad Sci U S A. 2006;103:5060–5065
- Role of galectin-3 in human pulmonary fibrosis. Allergol Int. 2007;56:57–65
- . Potentiation of iron accumulation in cardiac myocytes during the treatment of iron overload in gerbils with the hydroxypyridinone iron chelator CP94. Biometals. 1994;7:267–271
- Iron-induced oxidant stress in nonparenchymal liver cells: mitochondrial derangement and fibrosis in acutely iron-dosed gerbils and its prevention by silybin. J Bioenerg Biomembr. 2002;34:67–79
Supported by a grant from the National Blood Foundation (to L.K.).
PII: S1931-5244(09)00216-3
doi: 10.1016/j.trsl.2009.07.002
© 2009 Mosby, Inc. All rights reserved.
« Previous
Next »
Translational Research
Volume 154, Issue 4
, Pages 202-213
, October 2009
