Translational Research
Volume 155, Issue 4 , Pages 166-169 , April 2010

Mean leukocyte telomere length shortening and type 2 diabetes mellitus: a case-control study

  • Robert Y.L. Zee

      Affiliations

    • Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass
    • Corresponding Author InformationReprint requests: Robert Y.L. Zee, BDS, MPh, PhD, Laboratory of Genetic and Molecular Epidemiology, Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital, Harvard Medical School, 900 Commonwealth Avenue East, Boston, MA 02215
    • ,
  • Amy J. Castonguay

      Affiliations

    • Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass
    • ,
  • Nathaniel S. Barton

      Affiliations

    • Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass
    • ,
  • Soren Germer

      Affiliations

    • Department of Preclinical Research and Development, Hoffmann-La Roche, Nutley, NJ
    • ,
  • Mitchell Martin

      Affiliations

    • Department of Preclinical Research and Development, Hoffmann-La Roche, Nutley, NJ

Received 1 September 2009 ,Revised 23 September 2009 ,Accepted 30 September 2009.

References 

  1. Pickup JC, Mattock MB, Chusney GD, Burt D. NIDDM as a disease of the innate immune system: association of acute-phase reactants and interleukin-6 with metabolic syndrome X. Diabetologia. 1997;40:1286–1292
  2. Pickup JC, Crook MA. Is type II diabetes mellitus a disease of the innate immune system?. Diabetologia. 1998;41:1241–1248
  3. Fuster JJ, Andres V. Telomere biology and cardiovascular disease. Circ Res. 2006;99:1167–1180
  4. Fuster JJ, Diez J, Andres V. Telomere dysfunction in hypertension. J Hypertens. 2007;25:2185–2192
  5. Adaikalakoteswari A, Balasubramanyam M, Mohan V. Telomere shortening occurs in Asian Indian Type 2 diabetic patients. Diabet Med. 2005;22:1151–1156
  6. Adaikalakoteswari A, Balasubramanyam M, Ravikumar R, Deepa R, Mohan V. Association of telomere shortening with impaired glucose tolerance and diabetic macroangiopathy. Atherosclerosis. 2007;195:83–89
  7. Balasubramanyam M, Adaikalakoteswari A, Monickaraj SF, Mohan V. Telomere shortening & metabolic/vascular diseases. Indian J Med Res. 2007;125:441–450
  8. Tentolouris N, Nzietchueng R, Cattan V, et al. White blood cells telomere length is shorter in males with type 2 diabetes and microalbuminuria. Diabetes Care. 2007;30:2909–2915
  9. Sampson MJ, Winterbone MS, Hughes JC, Dozio N, Hughes DA. Monocyte telomere shortening and oxidative DNA damage in type 2 diabetes. Diabetes Care. 2006;29:283–289
  10. Zee RY, Germer S, Thomas A, et al. C-reactive protein gene variation and type 2 diabetes mellitus: a case-control study. Atherosclerosis. 2008;197:931–936
  11. Zee RY, Michaud SE, Germer S, Ridker PM. Association of shorter mean telomere length with risk of incident myocardial infarction: a prospective, nested case-control approach. Clin Chim Acta. 2009;403:139–141
  12. Kim S, Parks CG, DeRoo LA, et al. Obesity and weight gain in adulthood and telomere length. Cancer Epidemiol Biomarkers Prev. 2009;18:816–820
  13. Mirabello L, Huang WY, Wong JY, et al. The association between leukocyte telomere length and cigarette smoking, dietary and physical variables, and risk of prostate cancer. Aging Cell. 2009;8:405–413
  14. Nordfjall K, Eliasson M, Stegmayr B, Lundin S, Roos G, Nilsson PM. Increased abdominal obesity, adverse psychosocial factors and shorter telomere length in subjects reporting early ageing; the MONICA Northern Sweden Study. Scand J Public Health. 2008;36:744–752
  15. O'Callaghan NJ, Clifton PM, Noakes M, Fenech M. Weight loss in obese men is associated with increased telomere length and decreased abasic sites in rectal mucosa. Rejuvenation Res. 2009;12:169–176
  16. Zannolli R, Mohn A, Buoni S, et al. Telomere length and obesity. Acta Paediatr. 2008;97:952–954
  17. Brouilette SW, Moore JS, McMahon AD, et al. Telomere length, risk of coronary heart disease, and statin treatment in the West of Scotland Primary Prevention Study: a nested case-control study. Lancet. 2007;369:107–114
  18. Aviv A, Valdes A, Gardner JP, Swaminathan R, Kimura M, Spector TD. Menopause modifies the association of leukocyte telomere length with insulin resistance and inflammation. J Clin Endocrinol Metab. 2006;91:635–640
  19. Olivieri F, Lorenzi M, Antonicelli R, et al. Leukocyte telomere shortening in elderly Type2DM patients with previous myocardial infarction. Atherosclerosis. 2009;Epub ahead of print

 Supported by F. Hoffmann La-Roche.

PII: S1931-5244(09)00299-0

doi: 10.1016/j.trsl.2009.09.012

Translational Research
Volume 155, Issue 4 , Pages 166-169 , April 2010

Article Tools