Translational Research
Volume 155, Issue 5 , Pages 256-262 , May 2010

Isoenzyme profile of glutathione transferases in transitional cell carcinoma of upper urinary tract

  • Marija Matic

      Affiliations

    • Institute of Medical and Clinical Biochemistry, University of Belgrade, Belgrade, Serbia
  • ,
  • Tatjana Simic

      Affiliations

    • Institute of Medical and Clinical Biochemistry, University of Belgrade, Belgrade, Serbia
  • ,
  • Dejan Dragicevic

      Affiliations

    • Institute of Urology and Nephrology Faculty of Medicine, University of Belgrade, Belgrade, Serbia
  • ,
  • Jasmina Mimic-Oka

      Affiliations

    • Institute of Medical and Clinical Biochemistry, University of Belgrade, Belgrade, Serbia
  • ,
  • Marija Pljesa-Ercegovac

      Affiliations

    • Institute of Medical and Clinical Biochemistry, University of Belgrade, Belgrade, Serbia
  • ,
  • Ana Savic-Radojevic

      Affiliations

    • Institute of Medical and Clinical Biochemistry, University of Belgrade, Belgrade, Serbia
    • Corresponding Author InformationReprint requests: Ana Savic-Radojevic, MD, PhD, Institute of Medical and Clinical Biochemistry, Faculty of Medicine, University of Belgrade, Pasterova 2, 11000 Belgrade, Serbia

Received 21 August 2009 ,Revised 16 October 2009 ,Accepted 16 November 2009.

References 

  1. Kirkali Z, Tuzel E. Transitional cell carcinoma of the ureter and renal pelvis. Crit Rev Oncol Hematol. 2003;47:155–169
  2. Dragicevic D, Djokic M, Pekmezovic T, et al. Survival of patients with transitional cell carcinoma of the ureter and renal pelvis in Balkan endemic nephropathy and non-endemic areas of Serbia. BJU Int. 2007;99:1357–1362
  3. Tan LB, Chen KT, Guo HR. Clinical and epidemiological features of patients with genitourinary tract tumour in a blackfoot disease endemic area of Taiwan. BJU Int. 2008;102:48–54
  4. Simic T, Savic-Radojevic A, Pljesa-Ercegovac M, Matic M, Mimic-Oka J. Glutathione S-transferases in kidney and urinary bladder tumors. Nat Rev Urol. 2009;6:281–289
  5. Hayes JD, Strange RC. Glutathione S-transferase polymorphisms and their biological consequences. Pharmacology. 2004;61:154–166
  6. Townsend DM, Tew KD. The role of glutathione-S-transferase in anti-cancer drug resistance. Oncogene. 2003;22:7369–7375
  7. Filiadis I, Hrouda D. Genetic factors in chemically-induced transitional cell bladder cancer. BJU Int. 2000;86:794–801
  8. Their R, Golka K, Brüning T, Ko Y, Bolt HM. Genetic susceptibility to environmental toxicants: the interface between human and experimental studies in the development of new toxicological concepts. Toxicol Lett. 2002;127:321–327
  9. Lafuente A, Giralt M, Cervello I, Pujol F, Mallol J. Glutathione S-transferase activity in human superficial transitional cell carcinoma of the bladder. Comparison with healthy controls. Cancer. 1990;665:2064–2068
  10. Berendsen CL, Peters WHM, Scheffer PG, Bouman AA, Boven E, Newling DW. Glutathione S-transferase activity and subunit composition in transitional cell cancer and mucosa of the human bladder. Urology. 1997;49:644–651
  11. Simic T, Mimic-Oka J, Savic-Radojevic A, et al. Glutathione S-transferase T1-1 activity upregulated in transitional cell carcinoma of urinary bladder. Urology. 2005;65:1035–1040
  12. Savic-Radojevic A, Mimic-Oka J, Pljesa-Ercegovac M, et al. Glutathione S-transferase-P1 expression correlates with increased antioxidant capacity in transitional cell carcinoma of urinary bladder. Eur Urol. 2007;52:470–477
  13. Pljesa-Ercegovac M, Savic-Radojevic A, Dragicevic D, et al. Enhanced GSTP1 expression in transitional cell carcinoma of urinary bladder is associated with altered apoptotic pathways. Urol Oncol 2009;Jan 20. Epub ahead of print.
  14. Bradford MM. A rapid and sensitive method for quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976;72:248–254
  15. Habig WH, Jakoby WB. Assays for differentiation of glutathione S-transferases. Meth Enzymol 198;77:398–405.
  16. Berhane K, Widerstein M, Engström A, Kozarich JW, Mannervik B. Detoxication of base propenals and other α,β-unsaturated aldehyde products of radical reactions and lipid peroxidation by human glutathione transferases. Proc Natl Acad Sci U S A. 1994;91:1480–1484
  17. Their R, Wiebel FA, Hinkel A, et al. Species differences in the glutathione transferase GST1-1 activity towards the model substrates methyl chloride and dichloromethane in liver and kidney. Arch Toxicol. 1998;72:622–629
  18. Henderson JC, Wolf RC. Disruption of the glutathione transferase pi class gene. In:  Sies H,  Packer L editor. Methods enzymology. Glutathione transferases and gamma–glutamyl transpeptidases. New York: Elsevier; 2005;p. 116–136
  19. Lo HW, Ali-Osman F. Genetic polymorphism and function of glutathione S-transferases in tumor drug resistance. Curr Opin Pharmacol. 2007;7:367–374
  20. Turella P, Cerella C, Filomeni G, et al. Proapoptotic activity of new glutathione S-transferase inhibitors. Cancer Res. 2005;65:3751–3761
  21. Stenzl A, Cowan NC, De Santis M, et al. The updated EAU guidelines on muscle-invasive and metastatic bladder cancer. Eur Urol. 2009;55:815–825
  22. Adler V, Yin Z, Fuchs SY, et al. Regulation of JNK signaling by GSTp. EMBO J. 1999;18:1321–1334
  23. Davis RJ. Signal transduction by the JNK group of MAP kinases. Cell. 2000;103:239–252
  24. Tew KD, Ronai Z. GST function in drug and stress response. Drug Resist Updat. 1999;2:143–147
  25. Tew KD, Dutta S, Schultz M. Inhibitors of glutathione S-transferases as therapeutic agents. Adv Drug Deliv Rev. 1997;26:91–104
  26. Tew KD. TLK-286: a novel glutathione S-transferase-activated prodrug. Expert Opin Investig Drugs. 2005;14:1047–1054
  27. Byun SS, Kim SW, Choi H, Lee C, Lee E. Augmentation of cisplatin sensitivity in cisplatin-resistant human bladder cancer cells by modulating glutathione concentrations and glutathione-related enzyme activities. BJU Int. 2005;95:1086–1090
  28. Hurst R, Bao Y, Jemth P, Mannervik B, Williamson G. Phospholipid hydroperoxide glutathione peroxidase activity of human glutathione transferases. Biochem J. 1998;332:97–100
  29. Landi S. Mammalian class theta GST and differential susceptibility to carcinogens: a review. Mutat Res. 2000;463:247–283
  30. Bringuier PP, McCredie M, Sauter G, et al. Carcinomas of the renal pelvis associated with smoking and phenacetin abuse: p53 mutations and polymorphism of carcinogen-metabolising enzymes. Int J Cancer. 1998;79:531–536
  31. Golka K, Seidel T, Dietrich H, et al. Occupational and non-occupational risk factors in bladder cancer patients in an industrialized area located in former East-Germany. Aktuelle Urol. 2005;36:417–422

 Supported by Grant 145009DJ from the Serbian Ministry of Science.

PII: S1931-5244(09)00341-7

doi: 10.1016/j.trsl.2009.11.001

Translational Research
Volume 155, Issue 5 , Pages 256-262 , May 2010