Translational Research
Volume 155, Issue 4 , Pages 178-184 , April 2010

Cholesterol in pleural exudates depends mainly on increased capillary permeability

  • Luis Valdés

      Affiliations

    • Pulmonology Department, University Clinical Hospital Complex, Santiago de Compostela, A Coruña, Spain
    • Corresponding Author InformationReprint requests: Luis Valdés, PhD, Servicio de Neumología, Hospital de Conxo, Complexo Hospitalario Clínico Universitario de Santiago, Rúa Dr. Ramón Baltar s/n, 15706 Santiago de Compostela, A Coruña, Spain
    • ,
  • Esther San-José

      Affiliations

    • Clinical Analysis Department, University Clinical Hospital Complex, Santiago de Compostela, A Coruña, Spain
    • ,
  • Juan Carlos Estévez

      Affiliations

    • Department of Quantitative Economics, Faculty of Economics and Business Studies, University of Santiago de Compostela, Santiago de Compostela, A Coruña, Spain
    • ,
  • Francisco Javier González-Barcala

      Affiliations

    • Pulmonology Department, Hospital Complex Pontevedra, University Clinical Hospital Complex, Santiago de Compostela, A Coruña, Spain
    • ,
  • José Manuel Álvarez-Dobaño

      Affiliations

    • Pulmonology Department, University Clinical Hospital Complex, Santiago de Compostela, A Coruña, Spain
    • ,
  • Antonio Golpe

      Affiliations

    • Pulmonology Department, University Clinical Hospital Complex, Santiago de Compostela, A Coruña, Spain
    • ,
  • José Manuel Valle

      Affiliations

    • Pulmonology Department, University Clinical Hospital Complex, Santiago de Compostela, A Coruña, Spain
    • ,
  • Pedro Penela

      Affiliations

    • Pulmonology Department, University Clinical Hospital Complex, Santiago de Compostela, A Coruña, Spain
    • ,
  • Luis Vizcaíno

      Affiliations

    • Clinical Analysis Department, University Clinical Hospital Complex, Santiago de Compostela, A Coruña, Spain
    • ,
  • Antonio Pose

      Affiliations

    • Internal Medicine Department, University Clinical Hospital Complex, Santiago de Compostela, A Coruña, Spain

Received 31 August 2009 ,Revised 29 November 2009 ,Accepted 1 December 2009.

References 

  1. Hamm H, Brohan U, Bohmer R, Missmahl HP. Cholesterol in pleural effusions: a diagnotic aid. Chest. 1987;92:296–302
  2. Valdés L, Pose A, Suárez J, et al. Cholesterol: a useful parameter for distinguishing between pleural exudates and transudates. Chest. 1991;99:1097–1102
  3. Romero S, Candela A, Martin C, Hernández L, Trigo C, Gil J. Evaluation of different criteria for the separation of pleural transudates from exudates. Chest. 1993;104:399–404
  4. Valdés L. Estudio bioquímico de los derrames pleurales: utilidad del colesterol para diferenciar trasudados de exudados. [PhD dissertation] A Coruña, Spain: Universidad de Santiago de Compostela; 1994;
  5. Costa M, Quiroga T, Cruz E. Measurement of pleural fluid cholesterol and lactate dehydrogenase. A simple and accurate set of indicators for separating exudates from transudates. Chest. 1995;108:1260–1263
  6. Gil Suay V, Martínez Moragón E, Cases Viedma E, Perpiñá Tordera M, León Fábregas M, Sanchis Aldás J. Pleural cholesterol in differentiating transudates and exudates. A prospective study of 232 cases. Respiration. 1995;62:57–63
  7. Kalayci AG, Gürses N, Adam B, Albayrak D. Significance of pleural fluid cholesterol and beta-2 microglobulin levels for the differentiation of pleural effusions in childhood. Clin Pediatr. 1996;35:353–358
  8. Heffner JE, Brown LK, Barbieri CA. Diagnostic value of tests that discriminate between exudative and transudative pleural effusions. Primary Study Investigators. Chest. 1997;111:970–980
  9. Valdés L, Pose A, San José E, et al. Diagnostic value of cholesterol in pleural fluids. Eur J Intern Med. 1998;9:157–164
  10. Leers MP, Kleinveld HA, Scharnhorst V. Differentiating transudative from exudative pleural effusion: should we measure effusion cholesterol dehydrogenase?. Clin Chem Lab Med. 2007;45:1332–1338
  11. Sahn SA. State of the art: the pleura. Am Rev Respir Dis. 1988;138:184–234
  12. Pfalzer B, Hamm H, Beisiegel U. Ostendorf. Lipoproteins and apolipoproteins in human pleural effusions. J Lab Clin Med. 1992;120:483–493
  13. Vaz MAC, Teixeira LR, Vargas FS, et al. Relationship between pleural fluid and serum cholesterol levels. Chest. 2001;119:204–210
  14. García Pachón E, Llorca Escuin IL. Apolipoprotein A1 and apolipoprotein B in pleural effusions. Rev Clin Esp. 2005;205:363–366
  15. Sahn SA, Heffner JE. Pleural fluid analysis. In:  Light RW,  Lee YCG editor. Textbook of pleural fluids. London, UK: Arnold; 2003;p. 191–209
  16. Mahley RW, Weisgraber KW, Farese RV. Disorders of lipid metabolism. In:  Williams RH editors. Williams textbook of endocrinology. Philadelphia, PA: WB Saunders; 1998;p. 1099–1119

PII: S1931-5244(09)00348-X

doi: 10.1016/j.trsl.2009.12.001

Translational Research
Volume 155, Issue 4 , Pages 178-184 , April 2010

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