Translational Research
Volume 155, Issue 5 , Pages 228-237 , May 2010

Lung–lung interaction in isolated perfused unilateral hyperventilated rat lungs

  • Aishan Bilali

      Affiliations

    • Department of Critical Care Medicine, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
  • ,
  • Shunichi Kurata

      Affiliations

    • Department of Redox Response Cell Biology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
  • ,
  • Satoshi Ikeda

      Affiliations

    • Department of Pathology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
  • ,
  • Gabriela S. Georgieva

      Affiliations

    • Department of Critical Care Medicine, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
  • ,
  • Chenting Zhu

      Affiliations

    • Department of Critical Care Medicine, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
  • ,
  • Makoto Tomita

      Affiliations

    • Clinical Research Center, Medical Research Institute, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
  • ,
  • Iyoko Katoh

      Affiliations

    • Department of Microbiology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Kofu, Japan
  • ,
  • Chieko Mitaka

      Affiliations

    • Department of Critical Care Medicine, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
  • ,
  • Yoshinobu Eishi

      Affiliations

    • Department of Pathology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
  • ,
  • Takasuke Imai

      Affiliations

    • Department of Critical Care Medicine, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    • Corresponding Author InformationReprint requests: Takasuke Imai, MD, Department of Critical Care Medicine, Graduate School Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519 Japan

Received 16 July 2009 ,Revised 26 December 2009 ,Accepted 2 January 2010.

References 

  1. Montgomery A, Stager M, Caricco C, Hudson L. Causes of mortality in patients with the adult respiratory distress syndrome. Am Rev Respir Dis. 1985;132:485–489
  2. The Acute Respiratory Distress Syndrome Network. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med. 2000;342:1301–1308
  3. Kolobow T, Moretti M, Fumagalli R, et al. Severe impairment in lung function induced by high peak airway pressure during mechanical ventilation. An experimental study. Am Rev Respir Dis. 1987;135:312–315
  4. Tsuno K, Miura K, Takeya M, Kolobow T, Morioka T. Histopathologic pulmonary changes from mechanical ventilation at high peak airway pressures. Am Rev Respir Dis. 1991;143:1115–1120
  5. Dreyfuss D, Saumon G. Ventilator-induced lung injury. Lessons from experimental studies. Am J Respir Crit Care Med. 1998;157:294–323
  6. Tremblay L, Valenza F, Ribeiro SP, Li J, Slutsky AS. Injurious ventilatory strategies increase cytokines and c-fos m-RNA expression in an isolated rat lung model. J Clin Invest. 1997;99:944–952
  7. Ricard JD, Dreyfuss D, Saumon G. Production of inflammatory cytokines in ventilator-induced lung injury: a reappraisal. Am J Respir Crit Care Med. 2001;163:1176–1180
  8. Bethmann A, Brasch F, Nusing R, et al. Hyperventilation induces release of cytokines from perfused mouse lung. Am J Respir Crit Care Med. 1998;157:263–272
  9. Verbrugge SJC US, Neggers SJCMM, Martin C, Held HD, Haitsma JJ, Lachmann B. Different ventilation strategies affect lung function but do not increase tumor necrosis factor-α and prostacyclin production in lavaged rat lungs in vivo. Anesthesiology. 1999;91:1834–1843
  10. Imai T, Fujita T. Unilateral lung injury caused by ischemia without hypoxia in isolated rat lungs perfused with buffer solution. J Lab Clin Med. 1994;123:830–836
  11. Teng S, Kurata S, Katoh I, et al. Cytokine mRNA expression in unilateral ischemic-reperfused rat lung with salt solution supplemented with low-eondotoxin or standard bovine serum albumin. Am J Physiol Lung Cell Mol Physiol. 2004;286:L137–L142
  12. Georgieva GS, Kurata S, Ikeda S, et al. Prevention of ischemia reperfusion injury by positive pulmonary venous pressure in isolated rat lung. Shock. 2006;25:66–72
  13. Georgieva GS, Kurata S, Ikeda S, Eishi Y, Mitaka C, Imai T. Nonischemic lung injury by mediators from unilateral ischemic reperfused lung: ameliorating effect of tumor necrosis factor-α converting enzyme inhibitor. Shock. 2007;27:84–90
  14. Zhu C, Bilali A, Georgieva GS, Kurata S, Mitaka C, Imai T. Salvage of nonischemic control lung from injury by unilateral ischemic lung with apocynin, a nicotinamide adenine dinucleotide phosphate (NADPH) oxidase inhibitor, in isolated perfused rat lung. Transl Res. 2008;152:273–282
  15. Bierman A, Yerrapurddy A, Reddy NM, Hassoun PM, Reddy SP. Epidermal growth factor receptor (EGR) regulates mechanical ventilation-induced lung injury in mice. Transl Res. 2008;152:265–272
  16. Liu Y-Y, Liao S-K, Huang C-C, Tsai Y-H, Quinn DA, Li L-F. Role for nuclear factor-kB in augmented lung injury because of interaction between hyperoxia and high stretch ventilation. Transl Res. 2009;154:228–240
  17. Hsu S-M, Raine L, Fanger H. Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. J Histochem Cytochem. 1981;29:577–580
  18. Taylor C, Burns J. The demonstration of plasma cells and other immunoglobulin-containing cells in formalin-fixed, paraffin-embedded tissues using peroxidase-labeled antibody. J Clin Pathol. 1974;27:14–20
  19. Lau SK, Desrochers MJ, Luthringer DJ. Expression of thyroid transcription factor-1, cytokeratin 7, and cytokeratin 20 in bronchioloalveolar carcinomas: an immunohistochemical evaluation of 67 cases. Mod Pathol. 2002;15:538–542
  20. Kwast THvd, Stel HV, Cristen E, Bertina RM, Veerman ECI. Localization of factor VIII-procoagulant antigen: An immunohistological survey of the human body using monoclonal antibodies. Blood. 1986;67:222–227
  21. Wolthuis EK, Choi G, Dessing MC, et al. Mechanical ventilation with lower tidal volumes and positive end-expiratory pressure prevents pulmonary inflammation in patients without preexisting lung injury. Anesthesiology. 2008;108:46–54
  22. Determann RM, Wolthius EK, Choi G, et al. Lung epithelial injury markers are not influenced by use of lower tidal volumes during elective surgery in patients without preexisting lung injury. Am J Physiol Lung Cell Mol Physiol. 2008;294:L344–L350
  23. Mead J, Takishima T, Leith D. Stress distribution in lungs: a model of pulmonary elasticity. J Appl Physiol. 1970;28:596–608
  24. Gattinoni L, Caironi P, Cressoni M, et al. Lung recruitment in patients with the acute respiratory distress syndrome. N Engl J Med. 2006;354:1755–1786
  25. Terragni PP, Rosboch G, Tealdi A, et al. Tidal hyperinflation during low tidal volume ventilation in acute respiratory distress syndrome. Am J Respir Crit Care Med. 2007;175:160–166
  26. Berry EM, Edmonds JF, Wyllie JH. Release of prostaglandin E2 and unidentified factors from ventilated lugs. Br J Surg. 1971;58:189–192
  27. Plotz FB, Slutsky AS, Vught AJv, Heijnene CJ. Ventilator-induced lung injury and multiple system organ failure: a critical review of facts and hypotheses. Intensive Care Med. 2004;30:1865–1872
  28. Stuber F, Wrigge H, Schroeder S, Zinserling J, Hoeft A, Putensen C. Kinetic and reversibility of mechanical ventilation-assocaited pulmonary and systemic inflammatory response in patients with acute lung injury. Intensive Care Med. 2002;28:834–841
  29. Fujiwara K. Mechanical stresses keep endothelial cells healthy: beneficial effects of a physiological level of cyclic stretch on endothelial barrier function. Am J Physiol Lung Cell Mol Physiol. 2003;285:L782–L784
  30. Laffey JG, Engelberts D, Kavanagh BP. Injurious effects of hypocapnic alkalosis in the isolated lung. Am J Respir Crit Care Med. 2000;162:399–405
  31. Opal SM, DePalo VA. Anti-inflammatory cytokines. Chest. 2000;117:1162–1172
  32. Osuchowski MF, Welch K, Siddiqui J, Remick DG. Circulating cytokine/inhibitor profiles reshape the understanding of the SIRS/CARS continuum in sepsis and predict mortality. J Immunol. 2006;177:1967–1974
  33. Young I, Woodside J. Antioxidants in health and disease. J Clin Pathol. 2001;54:176–186
  34. Martinez-Caro L, Borente JA, Marin-Corral J, et al. Role of free radicals in vascular dysfunction induced by high tidal volume ventilation. Intensive Care Med. 2009;35:1110–1119
  35. Alemndros I, Gutierrez PT, Closa D, Navajas D, Farre R. One-lung overventilation does not induce inflammation in the normally ventilated contralateral lung. Respir Physiol Neurobiol. 2008;162:100–102

 Supported by Grants 17390481, 18659531, and 18-06471 from Grants-in-Aid for Scientific Research, from the Ministry of Education, Culture, Sports, Science and Technology of Japan.

PII: S1931-5244(10)00002-2

doi: 10.1016/j.trsl.2010.01.001

Translational Research
Volume 155, Issue 5 , Pages 228-237 , May 2010