Translational Research
Volume 155, Issue 5 , Pages 217-219 , May 2010

From a distance: ventilation-dependent extra-pulmonary injury

  • Wolfgang M. Kuebler

      Affiliations

    • Corresponding Author InformationReprint requests: Wolfgang M. Kuebler, The Keenan Research Centre, Li Ka Shing Knowledge Institute, St. Michael's Hospital, 30 Bond Street, Bond Wing 2-021, M5B 1W8 Toronto, Ontario, Canada

References 

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  4. Slutsky AS, Tremblay LN. Multiple system organ failure. Is mechanical ventilation a contributing factor?. Am J Respir Crit Care Med. 1998;157:1721–1725
  5. von Bethmann AN, Brasch F, Nusing R, et al. Hyperventilation induces release of cytokines from perfused mouse lung. Am J Respir Crit Care Med. 1998;157:263–272
  6. Kuebler WM, Uhlig U, Goldmann T, et al. Stretch activates nitric oxide production in pulmonary vascular endothelial cells in situ. Am J Respir Crit Care Med. 2003;168:1391–1398
  7. O'Mahony DS, Liles WC, Altemeier WA, et al. Mechanical ventilation interacts with endotoxemia to induce extrapulmonary organ dysfunction. Crit Care. 2006;10:R136
  8. Uhlig U, Dromann D, Goldmann T, et al. Pulmonary responses to overventilation in late multiple organ failure. Anesthesiology. 2006;105:1192–1200
  9. Montgomery AB, Stager MA, Carrico CJ, Hudson LD. Causes of mortality in patients with the adult respiratory distress syndrome. Am Rev Respir Dis. 1985;132:485–489
  10. Guery BP, Welsh DA, Viget NB, et al. Ventilation-induced lung injury is associated with an increase in gut permeability. Shock. 2003;19:559–563
  11. Imai Y, Parodo J, Kajikawa O, et al. Injurious mechanical ventilation and end-organ epithelial cell apoptosis and organ dysfunction in an experimental model of acute respiratory distress syndrome. JAMA. 2003;289:2104–2112
  12. Brander L, Sinderby C, Lecomte F, et al. Neurally adjusted ventilatory assist decreases ventilator-induced lung injury and non-pulmonary organ dysfunction in rabbits with acute lung injury. Intensive Care Med. 2009;35:1979–1989
  13. Bilali A, Kurata S, Ikeda S, et al. Lung-lung interaction in isolated perfused unilateral hyperventilated rat lungs. Transl Res. 2010;155:228–237
  14. Pries AR, Kuebler WM. Normal endothelium. Handb Exp Pharmacol. 2006;1–40
  15. Zhu L, He P. Platelet-activating factor increases endothelial [Ca2+]i and NO production in individually perfused intact microvessels. Am J Physiol Heart Circ Physiol. 2005;288:H2869–H2877
  16. Yang Y, Yin J, Baumgartner W, et al. Platelet-activating factor reduces endothelial NO production—role of acid sphingomyelinase. Eur Respir J. In press.

PII: S1931-5244(10)00031-9

doi: 10.1016/j.trsl.2010.01.006

Translational Research
Volume 155, Issue 5 , Pages 217-219 , May 2010

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