Translational Research
Volume 155, Issue 6 , Pages 315-319 , June 2010

Shortened activated partial thromboplastin time, a hemostatic marker for hypercoagulable state during acute coronary event

  • Wan Zaidah Abdullah

      Affiliations

    • Haematology Department, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kelantan, Malaysia
    • Corresponding Author InformationReprint requests: Dr. Wan Zaidah Abdullah, Haematology Department, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia
    • ,
  • Shaimaa K. Moufak

      Affiliations

    • Haematology Department, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kelantan, Malaysia
    • ,
  • Zurkurnai Yusof

      Affiliations

    • Cardiology Unit, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kelantan, Malaysia
    • ,
  • Mohd Sapawi Mohamad

      Affiliations

    • Cardiology Unit, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kelantan, Malaysia
    • ,
  • I.M. Kamarul

      Affiliations

    • Department of Community Medicine, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kelantan, Malaysia

Received 13 September 2009 ,Revised 7 February 2010 ,Accepted 9 February 2010.

References 

  1. Fareed J, Hoppensteadt DA, Leya F, Iqbal O, Wolf H, Bick R. Useful laboratory tests for studying thrombogenesis in acute cardiac syndromes. Clin Chem. 1998;44:1845–1853
  2. Kamphuisen PW, Eikenboom JC, Bertina RM. Elevated factor VIII levels and the risk of thrombosis. Arterioscler Thromb Vasc Biol. 2001;21:731–738
  3. Korte W, Clarke S, Lefkowitz JB. Short activated partial thromboplastin times are related to increased thrombin generation and an increased risk for thromboembolism. Am J Clin Pathol. 2000;113:123–127
  4. Nicolaes GA, Dahlback B. Congenital and acquired activated protein C resistance. Semin Vasc Med. 2003;3:33–46
  5. Redondo M, Carroll VA, Mauron T, et al. Hemostatic and fibrinolytic parameters in survivors of myocardial infarction: a low plasma level of plasmin-alpha2-antiplasmin complex is an independent predictor of coronary re-events. Blood Coag Fibr. 2001;12:495–499
  6. Ten Boekel E, Bock M, Vrielink GJ, Liem R, Hendriks H, de Kieviet W. Detection of shortened activated partial thromboplastin times: an evaluation of different commercial reagents. Thromb Res. 2007;121:361–367
  7. Ten BE, Bartels P. Abnormally short activated partial thromboplastin times are related to elevated plasma levels of TAT, F1+2, D-dimer and FVIII: C. Pathophysiol Haemost Thromb. 2002;32:137–142
  8. Legnani C, Mattarozzi S, Cini M, Cosmi B, Favaretto E, Palareti G. Abnormally short activated partial thromboplastin time values are associated with increased risk of recurrence of venous thromboembolism after oral anticoagulation withdrawal. Br J Haematol. 2006;134:227–232
  9. Tripodi A, Chantarangkul V, Martinelli I, Bucciarelli P, Mannucci PM. A shortened activated partial thromboplastin time is associated with the risk of venous thromboembolism. Blood. 2004;104:3631–3634
  10. Hamaad A, Sosin MD, Blann AD, Lip GY, Mac Fadven RJ. Markers of thrombosis and hemostasis in acute coronary syndromes: relationship to increased heart rate and reduced heart rate variability. Clin Cardiol. 2009;32:204–209

 Supported by Grant 1001/PPSP/812004 from the Universiti Sains Malaysia (USM)

PII: S1931-5244(10)00032-0

doi: 10.1016/j.trsl.2010.02.001

Translational Research
Volume 155, Issue 6 , Pages 315-319 , June 2010

Article Tools

* Image Usage & Resolution