Translational Research
Volume 156, Issue 2 , Pages 91-97 , August 2010

Using RB1 mutations to assess minimal residual disease in metastatic retinoblastoma

  • Helen Dimaras

      Affiliations

    • Divisions of Hematology/Oncology, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    • Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    • ,
  • Diane Rushlow

      Affiliations

    • Department of Retinoblastoma Solutions, University Health Network, University of Toronto, Ontario, Canada
    • ,
  • William Halliday

      Affiliations

    • Department of Pathology, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    • ,
  • John J. Doyle

      Affiliations

    • Divisions of Hematology/Oncology, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    • Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    • ,
  • Paul Babyn

      Affiliations

    • Department of Diagnostic Imaging, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    • ,
  • Esteban M. Abella

      Affiliations

    • Department of Pediatric Hematology-Oncology, Banner Children's Hospital, Mesa, Ariz
    • ,
  • James Williams

      Affiliations

    • Department of Pediatric Hematology-Oncology, Banner Children's Hospital, Mesa, Ariz
    • ,
  • Elise Héon

      Affiliations

    • Department of Ophthalmology/Visual Sciences, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    • ,
  • Brenda L. Gallie

      Affiliations

    • Department of Retinoblastoma Solutions, University Health Network, University of Toronto, Ontario, Canada
    • Department of Ophthalmology/Visual Sciences, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    • Department of Applied Molecular Oncology, University Health Network, University of Toronto, Ontario, Canada
    • ,
  • Helen S.L. Chan

      Affiliations

    • Divisions of Hematology/Oncology, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    • Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    • Corresponding Author InformationReprint requests: Helen Chan, Division of Hematology/Oncology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8

Received 14 January 2010 ,Revised 22 April 2010 ,Accepted 25 May 2010.

References 

  1. Chan HS, Gallie BL, Munier FL, Beck Popovic M. Chemotherapy for retinoblastoma. Ophthalmol Clin North Am. 2005;18:55–63
  2. Richter S, Vandezande K, Chen N, et al. Sensitive and efficient detection of RB1 gene mutations enhances care for families with retinoblastoma. Am J Hum Genet. 2003;72:253–269
  3. Rushlow D, Piovesan B, Zhang K, et al. Detection of mosaic RB1 mutations in families with retinoblastoma. Hum Mutat. 2009;30:842–851
  4. Chan HS, DeBoer G, Thiessen JJ, et al. Combining cyclosporin with chemotherapy controls intraocular retinoblastoma without requiring radiation. Clin Cancer Res. 1996;2:1499–1508
  5. Gallie BL, Budning A, DeBoer G, et al. Chemotherapy with focal therapy can cure intraocular retinoblastoma without radiotherapy. Arch Ophthalmol. 1996;114:1321–1328
  6. Chan HS, Canton MD, Gallie BL. Chemosensitivity and multidrug resistance to antineoplastic drugs in retinoblastoma cell lines. Anticancer Res. 1989;9:469–474
  7. Blaney SM, Heideman R, Berg S, et al. Phase I clinical trial of intrathecal topotecan in patients with neoplastic meningitis. J Clin Oncol. 2003;21:143–147
  8. Chalasani N, Said A, Ness R, Hoen H, Lumeng L. Screening for hepatocellular carcinoma in patients with cirrhosis in the United States: results of a national survey. Am J Gastroenterol. 1999;94:2224–2229
  9. Brisco MJ, Sykes PJ, Dolman G, et al. Effect of the Philadelphia chromosome on minimal residual disease in acute lymphoblastic leukemia. Leukemia. 1997;11:1497–1500
  10. Mensink E, van de Locht A, Schattenberg A, et al. Quantitation of minimal residual disease in Philadelphia chromosome positive chronic myeloid leukaemia patients using real-time quantitative RT-PCR. Br J Haematol. 1998;102:768–774
  11. Bowles E, Corson TW, Bayani J, et al. Profiling genomic copy number changes in retinoblastoma beyond loss of RB1. Genes Chromosomes Cancer. 2007;46:118–129

 Supported by grants from The Ontario Institute for Cancer Research and from the Canadian Retinoblastoma Society and the Royal Arch Masons of Canada. Funded in part by the Ontario Ministry of Health and Long Term Care (OMOHLTC). The views expressed do not necessarily reflect those of the OMOHLTC.

PII: S1931-5244(10)00115-5

doi: 10.1016/j.trsl.2010.05.009

Translational Research
Volume 156, Issue 2 , Pages 91-97 , August 2010

Article Tools

* Image Usage & Resolution