Translational Research
Volume 159, Issue 2 , Pages 61-63 , February 2012

High points and hurdles in the translation of genomics

  • Jill Waalen

      Affiliations

    • Corresponding Author InformationReprint requests: Jill Waalen, MD, MPH, The Scripps Research Institute, Department of Molecular and Experimental Medicine, 10550 North Torrey Pines Road, La Jolla, CA 92037.

References 

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  2. Marian AJ. Molecular genetic studies of complex phenotypes. Transl Res. 2012;159:64–79
  3. The road to the $1000 genome-a roundup of sequencing technology developments. National Human Genome Research Institute. Available at: http://www.genome.gov/27540667. Accessed October 27, 2011.
  4. GWAS integrator [Internet]. National Human Genome Research Institute. Available at: http://hugenavigator.net/HuGENavigator/gWAHit.do?query=&typeSubmitAll=+Statistics+&Mysubmit=simple&geneOrderType=geneA. Accessed October 27, 2011.
  5. Epidemiology and genomics research [Internet]. National Cancer Institute. Available at: http://epi.grants.cancer.gov/pgwas. Accessed October 27, 2011.
  6. Manolio TA. Genome-wide association studies and the assessment of risk. N Engl J Med. 2010;363:166–176
  7. Green ED, Guyer MS. Charting a course for genomic medicine from base pairs to bedside. Nature. 2011;470:204–213
  8. Worthey EA, Mayer AN, Syverson GD, et al. Making a definitive diagnosis: successful clinical application of whole exome sequencing in a child with intractable inflammatory bowel disease. Genet Med. 2011;13:255–262
  9. Lavelle J. Scripps announces pioneering genetic study. San Diego Union Tribune. 2011;Oct 18:Sect A:1
  10. Sheffield VC, Stone EM. Genomic medicine: genomics and the eye. N Engl J Med. 2011;364:1932–1942
  11. Herder C, Karakas M, Koenig W. Biomarkers for the prediction of type 2 diabetes and cardiovascular disease. Clin Pharmacol Ther. 2011;90:52–66
  12. Hudson KL. Genomics, health care and society. N Engl J Med. 2011;365:1033–1041
  13. Wizemann T, Berger AC. The value of genetic and genomic technologies: workshop summary. Roundtable on translating genomic-based research for health. Washington, DC: National Academies Press; 2011;26
  14. Chen P, Lin JJ, Lu CS, et al. Carbamazepine-induced toxic effects and HLA-B∗1502 screening in Taiwan. N Eng J Med. 2011;364:1126–1133

PII: S1931-5244(11)00380-X

doi: 10.1016/j.trsl.2011.10.013

Translational Research
Volume 159, Issue 2 , Pages 61-63 , February 2012

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