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Article Title |
Author(s) |
Type (Status) |
Available Online |
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Dopamine receptor D1 mediates the inhibition of dopamine on the distal colonic motility
DOI: 10.1016/j.trsl.2012.01.002
The motility of distal colon could be inhibited by dopamine (DA), yet, the involved receptor is controversial according to the published reports. The goal of present study was to investigate DA recept...
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Xiaohui Zhang,
Hua Guo,
Jindong Xu,
Yun Li,
Lisheng Li,
Xiaoli Zhang,
Xiaofeng Li,
Rifang Fan,
Yue Zhang,
Zhongping Duan,
Jinxia Zhu
et al.
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Full-length article
(In Press Uncorrected Proof)
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27 January 2012 |
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Developing and assessing cardiovascular biomarkers
DOI: 10.1016/j.trsl.2012.01.003
Atherosclerosis is a slow process that over time can lead to fatal events. Early identification and prediction of future risk can allow for preventive strategies to be instituted. There is an increasi...
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Razvan T. Dadu,
Vijay Nambi,
Christie M. Ballantyne
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Review article
(In Press Uncorrected Proof)
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27 January 2012 |
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Genetic and immune predictors for hypersensitivity syndrome to antiepileptic drugs
DOI: 10.1016/j.trsl.2012.01.004
Hypersensitivity syndrome reactions (HSR) to antiepileptic drugs (AED) are associated with severe clinical cutaneous adverse reactions (SCAR). We aimed (1) to assess HSRs to AEDs using the in vitro ly...
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Manuela G. Neuman,
Lawrence Cohen,
Radu M. Nanau,
Paul A. Hwang
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Full-length article
(In Press Uncorrected Proof)
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27 January 2012 |
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Translational research in infectious disease: current paradigms and challenges ahead
DOI: 10.1016/j.trsl.2011.12.009
In recent years, the biomedical community has witnessed a rapid scientific and technologic evolution after the development and refinement of high-throughput methodologies. Concurrently and consequenti...
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Judith M. Fontana,
Elizabeth Alexander,
Mirella Salvatore
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Review article
(In Press Uncorrected Proof)
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16 January 2012 |
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Role of advanced glycation endproducts and glyoxalase I in diabetic peripheral sensory neuropathy
DOI: 10.1016/j.trsl.2011.12.004
Diabetic neuropathy is the most common and debilitating complication of diabetes mellitus with more than half of all patients developing altered sensation as a result of damage to peripheral sensory n...
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M.M. Jack,
D.E. Wright
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Review article
(In Press Uncorrected Proof)
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11 January 2012 |
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Treating hepatitis C infection by targeting the host
DOI: 10.1016/j.trsl.2011.12.007
More than 130 million people worldwide are chronically infected with the hepatitis C virus (HCV), which can lead to cirrhosis, liver failure, and hepatocellular carcinoma. Although recently approved H...
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Shadi Salloum,
Andrew W. Tai
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Review article
(In Press Uncorrected Proof)
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11 January 2012 |
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Chronic kidney disease as a risk factor for acute coronary syndromes in patients presenting to the emergency room with chest pain
DOI: 10.1016/j.trsl.2011.12.006
We sought to determine whether persons with intermediate risk factors for cardiovascular disease presenting to an emergency department with chest pain and chronic kidney disease (CKD) were triaged eff...
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Sherezade Khambatta,
Michael E. Farkouh,
R. Scott Wright,
Guy S. Reeder,
Peter A. Mccullough,
Peter A. Smars,
Latonya J. Hickson,
Patricia J.M. Best
et al.
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Full-length article
(In Press Uncorrected Proof)
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10 January 2012 |
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Effect of oxidative stress and endotoxin on human serum albumin in brain-dead organ donors
DOI: 10.1016/j.trsl.2011.12.005
Albumin, among other molecules, binds and detoxifies endotoxin in healthy people. Oxidative stress leads to protein oxidation and thus to the impaired binding properties of albumin. This property, in ...
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Bettina Leber,
Vanessa Stadlbauer,
Philipp Stiegler,
Stefanie Stanzer,
Ursula Mayrhauser,
Sonja Koestenbauer,
Barbara Leopold,
Michael Sereinigg,
Andreas Puntschart,
Tatjana Stojakovic,
Karl-Heinz Tscheliessnigg,
Karl Oettl
et al.
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Full-length article
(In Press Uncorrected Proof)
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09 January 2012 |
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Review of novel clinical applications of advanced, real-time, 3-dimensional echocardiography
DOI: 10.1016/j.trsl.2011.12.008
Advances in computer processing speed and memory along with the advent of the microbeam former that can sample an entire crystal of the ultrasound transducer made possible the performance of 3-dimensi...
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Manjula V. Burri,
Dipti Gupta,
Richard E. Kerber,
Robert M. Weiss
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Review article
(In Press Uncorrected Proof)
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09 January 2012 |
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Molecular imaging of disease with targeted contrast ultrasound imaging
DOI: 10.1016/j.trsl.2011.12.001
To enhance clinical care for patients, methods for noninvasive imaging of specific disease-related molecular changes are being developed to expand and improve diagnostic capabilities. These new techni...
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Yoichi Inaba,
Jonathan R. Lindner
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Review article
(In Press Uncorrected Proof)
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06 January 2012 |
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Silibinin modulates lipid homeostasis and inhibits nuclear factor kappa B activation in experimental nonalcoholic steatohepatitis
DOI: 10.1016/j.trsl.2011.12.003
Nonalcoholic steatohepatitis (NASH) is associated with increased liver-related mortality. Disturbances in hepatic lipid homeostasis trigger oxidative stress and inflammation (ie, lipotoxicity), leadin...
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Federico Salamone,
Fabio Galvano,
Francesco Cappello,
Andrea Mangiameli,
Ignazio Barbagallo,
Giovanni Li Volti
et al.
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Full-length article
(In Press Uncorrected Proof)
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04 January 2012 |
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Accelerated senescence of renal tubular epithelial cells is associated with disease progression of patients with immunoglobulin A (IgA) nephropathy
DOI: 10.1016/j.trsl.2011.11.008
The aim of this study is to determine the potential correlation between the accelerated senescence of renal tubular epithelial cells (RTECs) and the disease progression of patients with immunoglobulin...
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Jun Liu,
Ju-Rong Yang,
Ya-Ni He,
Jian-Guo Zhang,
Li-Rong Lin,
Jun Zhan,
Jin-Hua Zhang,
Hua-Shi Xiao
et al.
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Full-length article
(In Press Uncorrected Proof)
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28 December 2011 |
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Inflammatory bowel disease and pregnancy: overlapping pathways
DOI: 10.1016/j.trsl.2011.12.002
Several studies have reported on the association between inflammatory bowel disease (IBD) and adverse pregnancy outcomes, such as preterm birth. The exact mechanisms of action are unclear; however, se...
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Noha Ahmed Nasef,
Lynnette R. Ferguson
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Review article
(In Press Uncorrected Proof)
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26 December 2011 |
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Canine tumors: a spontaneous animal model of human carcinogenesis
DOI: 10.1016/j.trsl.2011.11.005
The enormous biologic complexity of human cancer has stimulated the development of more appropriate experimental models that could resemble in a natural and spontaneous manner the physiopathologic asp...
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Salomé S Pinho,
Sandra Carvalho,
Joana Cabral,
Celso A Reis,
Fátima Gärtner
et al.
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Review article
(In Press Uncorrected Proof)
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22 December 2011 |
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Keloids: what do we know and what do we do next?
DOI: 10.1016/j.trsl.2011.11.007
It is believed that the knowledge of excessive scarring and keloids as a pathologic consequence of cutaneous injury was first described in approximately 1700 bce as outlined in the Edwin Smith Papyrus...
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Patrick H. Blit,
Marc G. Jeschke
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Discussion
(In Press Uncorrected Proof)
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19 December 2011 |
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Cardiovascular translational imaging: From bench to bedside
DOI: 10.1016/j.trsl.2011.11.006
Over the last 4 decades, heart disease mortality has declined at a rate of 2.5% per year. This remarkable achievement has been attributed primarily to advances in the management of cardiovascular risk...
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Mario J. Garcia
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Discussion
(In Press Uncorrected Proof)
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15 December 2011 |
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Intracardiac T-wave alternans, ischemia, and arrhythmias, in a canine model
DOI: 10.1016/j.trsl.2011.11.003
I enjoyed reading the article by Kwofie et al in the November 2011 issue of Translational Research, pertaining to the employment of intracardiac bipolar electrograms (IBEs)-based T-wave alternans (TWA...
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John E. Madias
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Correspondence
(In Press Uncorrected Proof)
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12 December 2011 |
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Reply to “Intracardiac T-wave alternans, ischemia, and arrhythmias, in a canine model”
DOI: 10.1016/j.trsl.2011.11.004
We appreciate the interest in the article on T-wave alternans (TWA) and arrhythmia. The issues of interest that were raised in the initial letter to the editor are addressed in the following paragraph...
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Michael A. Kwofie,
James B. Martins
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Correspondence
(In Press Uncorrected Proof)
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12 December 2011 |
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Biomarkers in acute myocardial injury
DOI: 10.1016/j.trsl.2011.11.002
Acute coronary syndrome (ACS) is a significant cause of morbidity and mortality worldwide. The proper diagnosis of ACS requires reliable and accurate biomarker assays to detect evidence of myocardial ...
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Devin W. Kehl,
Navaid Iqbal,
Arrash Fard,
Ben A. Kipper,
Alejandro De La Parra Landa,
Alan S. Maisel
et al.
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Review article
(In Press Uncorrected Proof)
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09 December 2011 |
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Uncoupling protein-2 expression and effects on mitochondrial membrane potential and oxidant stress in heart tissue
DOI: 10.1016/j.trsl.2011.11.001
Myocardial uncoupling protein (UCP)-2 is increased with chronic peroxisome proliferator-activated receptor γ (PPARγ) stimulation, but the effect on membrane potential and superoxide is unclear. Wild-t...
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Jesús A. Cabrera,
Elizabeth A. Ziemba,
Robert Colbert,
Rosemary F. Kelly,
Michael Kuskowski,
Edgar Arriaga,
Wim Sluiter,
Dirk J. Duncker,
Herbert B. Ward,
Edward O. Mcfalls
et al.
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Full-length article
(In Press Uncorrected Proof)
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05 December 2011 |
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Single-nucleotide polymorphisms in inflammatory bowel disease
DOI: 10.1016/j.trsl.2011.10.006
Strong evidence indicates that inflammatory bowel disease, including Crohn disease and ulcerative colitis, is a result of an inappropriate inflammatory response in which genetic and environmental fact...
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Manuela G. Neuman,
Radu M. Nanau
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Review article
(In Press Uncorrected Proof)
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24 November 2011 |
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Genetic analysis of the promoter region of the GATA4 gene in patients with ventricular septal defects
DOI: 10.1016/j.trsl.2011.10.012
Ventricular septal defects (VSDs) are the most common type of congenital heart diseases (CHDs). To date, the genetic causes for sporadic VSDs remain largely unknown. GATA transcription factor 4 (GATA4...
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Guanghua Wu,
Jiping Shan,
Shuchao Pang,
Xiaodan Wei,
Hao Zhang,
Bo Yan
et al.
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Full-length article
(In Press Uncorrected Proof)
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24 November 2011 |
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Genetic origin and interaction of the Filipino β0-thalassemia with Hb E and α-thalassemia in a Thai family
DOI: 10.1016/j.trsl.2011.10.008
We describe hematologic and molecular characteristics of a hitherto undescribed interaction between the Filipino deletional β0-thalassemia with Hb E and α-thalassemia in a Thai family. This study was ...
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Supawadee Yamsri,
Kanokwan Sanchaisuriya,
Goonnapa Fucharoen,
Supan Fucharoen
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Full-length article
(In Press Uncorrected Proof)
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18 November 2011 |
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Imaging atherosclerosis in HIV: carotid intima-media thickness and beyond
DOI: 10.1016/j.trsl.2011.10.007
Chronic immune activation and inflammation are associated with an increased risk of atherosclerosis in HIV-infected patients. In this review, we discuss the role of established and novel imaging modal...
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Chris T. Longenecker,
Brian D. Hoit
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Review article
(In Press Uncorrected Proof)
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15 November 2011 |
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Chronic inflammation and pain in a tumor necrosis factor receptor (TNFR) (p55/p75-/-) dual deficient murine model
DOI: 10.1016/j.trsl.2011.10.003
Many aspects of tissue damage after acute or chronic inflammatory reactions can be attributed directly to the concomitant biosynthesis and release of inducible early proinflammatory cytokine tumor nec...
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Karin W. Westlund,
Liping Zhang,
Fei Ma,
Helieh S. Oz
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Full-length article
(In Press Uncorrected Proof)
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10 November 2011 |
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Altered angiogenic balance in keloids: a key to therapeutic intervention
DOI: 10.1016/j.trsl.2011.10.002
Keloids are manifestations of abnormal wound repair with unresolved clinical complications. An effective therapeutic regimen has not been established for keloids, and current strategies are plagued by...
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Nirupa Shyam Mogili,
Venkat Raghavan Krishnaswamy,
Meenakshi Jayaraman,
Rama Rajaram,
Alamelu Venkatraman,
Purna Sai Korrapati
et al.
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Full-length article
(In Press Uncorrected Proof)
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07 November 2011 |
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Erythromycin ameliorates cigarette-smoke–induced emphysema and inflammation in rats
DOI: 10.1016/j.trsl.2011.09.007
The exposure to cigarette smoke (CS) is associated with emphysema. In addition to chronic lung inflammation, emphysema is known mainly for the complex pathogenesis associated with imbalance of proteol...
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Yan Zhou,
Xianshu Tan,
Wenjuan Kuang,
Litao Liu,
Lihong Wan
et al.
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Full-length article
(In Press Uncorrected Proof)
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24 October 2011 |
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Multimodal sentinel lymph node mapping with single-photon emission computed tomography (SPECT)/computed tomography (CT) and photoacoustic tomography
DOI: 10.1016/j.trsl.2011.09.006
The identification of cancer cells in the lymph nodes surrounding a tumor is important in establishing a prognosis. Optical detection techniques such as fluorescence and photoacoustic tomography (PAT)...
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Walter J. Akers,
W. Barry Edwards,
Chulhong Kim,
Baogang Xu,
Todd N. Erpelding,
Lihong V. Wang,
Samuel Achilefu
et al.
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Full-length article
(In Press Uncorrected Proof)
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24 October 2011 |
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Inflammatory bowel disease: role of diet, microbiota, life style
DOI: 10.1016/j.trsl.2011.09.001
Inflammatory bowel disease (IBD) encompassed several chronic inflammatory disorders leading to damage of the gastrointestinal tract (GI). The 2 principal forms of these disorders are ulcerative coliti...
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Manuela G. Neuman,
Radu M. Nanau
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Review article
(In Press Uncorrected Proof)
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26 September 2011 |
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Metabolome and inflammasome in inflammatory bowel disease
DOI: 10.1016/j.trsl.2011.08.006
Inflammatory bowel disease (IBD) encompasses several chronic inflammatory disorders leading to the damage of the gastrointestinal tract. The 2 principal forms of these disorders are ulcerative colitis...
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Radu M. Nanau,
Manuela G. Neuman
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Review article
(In Press Uncorrected Proof)
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16 September 2011 |
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Estrogen-related MxA transcriptional variation in hepatitis C virus-infected patients
DOI: 10.1016/j.trsl.2011.08.002
Sex has been reported to influence the rates of viral clearance in hepatitis C virus (HCV)-infected patients. However, little is known regarding the influence of sex on the host genetic response to HC...
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Radwa Y. Mekky,
Nabila Hamdi,
Wafaa El-Akel,
Gamal Esmat,
Ahmed I. Abdelaziz
et al.
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Full-length article
(In Press Uncorrected Proof)
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05 September 2011 |
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Molecular profiling of individual tumor cells by hyperspectral microscopic imaging
DOI: 10.1016/j.trsl.2011.08.003
We developed a hyperspectral microscopic imaging (HMI) platform that can precisely identify and quantify 10 molecular markers in individual cancer cells in a single pass. The exploitation of an improv...
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Jonathan W. Uhr,
Michael L. Huebschman,
Eugene P. Frenkel,
Nancy L. Lane,
Raheela Ashfaq,
Huaying Liu,
Dipen R. Rana,
Lawrence Cheng,
Alice T. Lin,
Gareth A. Hughes,
Xiaojing J. Zhang,
Harold R. Garner
et al.
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Full-length article
(In Press Uncorrected Proof)
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05 September 2011 |
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γδ T cells and Th17 cytokines in hypersensitivity pneumonitis and lung fibrosis
DOI: 10.1016/j.trsl.2009.07.011
Hypersensitivity pneumonitis (HP) is an inflammatory lung disease caused by repeated inhalation of aerosolized antigens. With chronic exposure to an inhaled antigen, patients are at risk of developing...
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Philip L. Simonian,
Christina L. Roark,
Willi K. Born,
Rebecca L. O'Brien,
Andrew P. Fontenot
et al.
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Review article
(In Press Uncorrected Proof)
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24 August 2009 |