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IFC
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High points and hurdles in the translation of genomics
23 November 2011
When the sequencing of the human genome was completed 8 years ago, it was the result of nearly 13 years of work by multiple groups using techniques that sequenced DNA base pairs at a rate of 115,000 (...
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Jill Waalen
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61-63
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| Review Article |
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Molecular genetic studies of complex phenotypes
01 September 2011
The approach to molecular genetic studies of complex phenotypes evolved considerably during the recent years. The candidate gene approach, which is restricted to an analysis of a few single-nucleotide...
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Ali J. Marian
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64-79
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| Featured New Investigator |
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Prematurity in mice leads to reduction in nephron number, hypertension, and proteinuria
10 November 2011
The nephron number at birth is a quantitative trait that correlates inversely with the risk of hypertension and chronic kidney disease later in life. During kidney development, the nephron number is c...
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Cary Stelloh,
Kenneth P. Allen,
David L. Mattson,
Alexandra Lerch-Gaggl,
Sreenivas Reddy,
Asraf El-Meanawy
et al.
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80-89
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The combined ratios of L-arginine and asymmetric and symmetric dimethylarginine as biomarkers in spontaneously hypertensive rats
29 September 2011
Hypertension and hypertensive end-organ damage have been associated with decreased nitric oxide (NO) bioavailability. Asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) both can ...
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Chien-Ning Hsu,
Li-Tung Huang,
Ying-Tung Lau,
Ching-Yuang Lin,
You-Lin Tain
et al.
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90-98
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Enhanced induction of heme oxygenase-1 suppresses thrombus formation and affects the protein C system in sepsis
17 November 2011
Heme oxygenase-1 (HO-1) displays anti-inflammatory and cytoprotective activities in sepsis. Here, we investigated the effects of HO-1 on thrombus formation and the protein C system in a septic C57BL/6...
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Dongsheng Fei,
Xianglin Meng,
Mingran Zhao,
Kai Kang,
Gang Tan,
Shangha Pan,
Yunpeng Luo,
Wen Liu,
Chuanchuan Nan,
Hongchi Jiang,
Geoffrey W. Krissansen,
Mingyan Zhao,
Xueying Sun
et al.
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99-109
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Mild hypothermia reduces ventilator–induced lung injury, irrespective of reducing respiratory rate
14 November 2011
In the era of lung-protective mechanical ventilation using limited tidal volumes, higher respiratory rates are applied to maintain adequate minute volume ventilation. However, higher respiratory rates...
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Hamid Aslami,
Maria T. Kuipers,
Charlotte J.P. Beurskens,
Joris J.T.H. Roelofs,
Marcus J. Schultz,
Nicole P. Juffermans
et al.
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110-117
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Link between leptin and interleukin-6 levels in the initial phase of obesity related inflammation
07 November 2011
The mechanisms underlying the pathogenesis of obesity-related atherosclerosis remain to be clarified. To investigate the preclinical phase, interleukin-6 (IL-6) plasma levels were analyzed together wi...
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Ingeborg Stelzer,
Sieglinde Zelzer,
Reinhard B. Raggam,
Florian Prüller,
Martie Truschnig-Wilders,
Andreas Meinitzer,
Wolfgang J. Schnedl,
Renate Horejsi,
Reinhard Möller,
Daniel Weghuber,
Gloria Reeves,
Teodor T. Postolache,
Harald Mangge
et al.
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118-124
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Information for Readers
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IBC
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Contents
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OBC
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Masthead
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A1
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Editorial Advisory Board
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A2
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Author Guidelines
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A3-A5
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