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Abstract
Tests for sensitivity to commercial penicillin in vitro have been carried out on 240
pathogenic strains of gonococcus, beta and alpha streptococcus, pneumococcus, meningococcus,
and staphylococcus and also on twenty-one respiratory strains of H. hemolyticus. There were wide differences in sensitivity among these organisms and among different
strains of the same organism.
The strains of gonococcus and of Group A hemolytic streptococcus were the most sensitive
to penicillin and showed the greatest uniformity in that respect. The strains of staphylococcus
and meningococcus showed the widest range of sensitivity. Most of the H. hemolyticus strains reacted like the majority of staphylococci and meningococci. The sensitivity
of strains of pneumococcus and alpha streptococcus was intermediate between that of
beta streptococci and meningococci.
Resistant strains, which were 256 times more resistant than the reference strain of
hemolytic streptococcus, were encountered only among the staphylococci. Relatively
insensitive strains, which were from sixteen to sixty-four times more resistant than
the reference strain, were found among the staphylococci, meningococci, H. hemolyticus, and alpha streptococci.
Among the Group A streptococci, pneumococci, and meningococci there was no correlation
between the serologic types and penicillin sensitivity. Among the pathogenic staphylococci
there was no apparent relation between penicillin sensitivity and the hemolytic or
coagulase properties of the different strains.
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Article info
Publication history
Received:
June 25,
1945
Footnotes
☆Part of the penicillin used in this study was provided by the Office of Scientific Research and Development from supplies assigned by the Committee on Medical Research for clinical investigations recommended by the Committee on Chemotherapeutic and Other Agents of the National Research Council.
Identification
Copyright
© 1945 Published by Elsevier Inc.