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Under conditions of nearly constant pH, 0.1 per cent Aerosol OT increases the phenol coefficient of germicides in the F. D. A. method (special), Staph.aureus, 37 °C., as follows : phenol, from 1.0 to 1.8; U. S. P. cresol, from 2.4 to 4.4; U. S. P. tincture of iodine (strong), doubtfully and irregularly from 3.7-4.3 to 4.3–5.5. The apparent phenol coefficient of phenylmercuric nitrate (not corrected for bacteriostasis) is increased from 166 to 1,300. The characteristics of Aerosol OT as a potentiating agent for germicides are described.
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Received: April 26, 1945
© 1945 Published by Elsevier Inc.