Research Article| Volume 36, ISSUE 4, P501-510, October 1950

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Indican excretion in relation to intestinal sterilization

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      A combination of streptomycin and glucuronic acid was given orally to a group of six patients. This group of patients was followed with quantitative stool cultures and quantitative urinary indican determinations at daily intervals.
      In five of the six patients it was found that the excretion of indican did not diminish when organisms were eliminated from the stools.
      It is apparent that the urinary indican excretion is not dependent on Esch. coli activity in the bowel. This necessitates some modification in the concept of “intestinal putrefaction.”
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      1. Mast, G. M., and Harrison, P.: Unpublished data.

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