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Erythrocyte survival studies, using the method of differential hemagglutination on capillary blood samples, are easily performed in infants and children. Withdrawal of blood for survival study from children with a variety of hematologic disorders is not attended by any distress or untoward sequellae for the patient when immediate replacement is made as indicated.
Subjects of small size are particularly suitable as recipients of tagged erythrocytes since small transfusions yield relatively high donor cell counts. The results obtained with normal subjects and with subjects with sickle cell anemia and congenital hemolytic icterus conform to those of previous workers and form the basis for the interpretation of original observations in a variety of hemolytic disorders in childhood.
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Received: May 25, 1950With the Technical Assistance of Linda Hoogana, M.S.
© 1950 Published by Elsevier Inc.