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Research Article| Volume 36, ISSUE 4, P511-516, October 1950

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Erythrocyte survival studies in childhood

I. Methods and general observations
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      Abstract

      Erythrocyte survival studies, using the method of differential hemagglutination on capillary blood samples, are easily performed in infants and children. Withdrawal of blood for survival study from children with a variety of hematologic disorders is not attended by any distress or untoward sequellae for the patient when immediate replacement is made as indicated.
      Subjects of small size are particularly suitable as recipients of tagged erythrocytes since small transfusions yield relatively high donor cell counts. The results obtained with normal subjects and with subjects with sickle cell anemia and congenital hemolytic icterus conform to those of previous workers and form the basis for the interpretation of original observations in a variety of hemolytic disorders in childhood.
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      References

        • Dacie J.V.
        • Mollison P.L.
        Survival of Normal Erythrocytes After Transfusion to Patients With Familial Hemolytic Anemia.
        Lancet. 1943; 244: 550
        • Loutit J.F.
        • Mollison P.L.
        Hemolytic Icterus (Acholuric Jaundice) Congenital and Acquired.
        J. Path. & Bact. 1946; 58: 711
        • Singer K.
        • Robin S.
        • King J.
        • Jefferson R.
        The Life Span of the Sickle Cell and the Pathogenesis of Sickle Cell Anemia.
        J. Lab. & Clin. Med. 1948; 33: 975
        • Callender S.T.E.
        • Nickel J.F.
        • Moore C.V.
        Sickle Cell Disease: Studied by Measuring the Survival of Transfused Red Blood Cells.
        J. Lab. & Clin. Med. 1949; 34: 90
        • Dacie J.V.
        • Mollison P.L.
        Survival of Transfused Erythrocytes From a Donor With Nocturnal Hemoglobinuria.
        Lancet. 1949; 141: 390
        • Singer K.
        • King J.C.
        • Robin S.
        The Life Span of the Megalocyte and the Hemolytic Syndrome of Pernicious Anemia.
        J. Lab. & Clin. Med. 1948; 33: 1068
        • Young L.E.
        • Platzer R.F.
        • Rafferty J.A.
        Differential Agglutination of Human Erythrocytes.
        J. Lab. & Clin. Med. 1947; 32: 489
        • Barkan G.
        • Walker B.S.
        Determination of Serum Iron and Pseudohemoglobin Iron with O-Phenanthroline.
        J. Biol. Chem. 1940; 135: 37
        • Cartwright G.E.
        • Wintrobe M.M.
        Chemical, Clinical and Immunological Studies on the Products of Human Plasma Fractionation. XXXIX. The Anemia of Infection, Studies on the Iron-Binding Capacity of Serum.
        J. Clin. Investigation. 1949; 28: 86
        • Shen S.C.
        • Castle W.B.
        • Fleming E.M.
        Experimental and Clinical Observations on Increased Mechanical Fragility of Erythrocytes.
        Science. 1944; 100: 387
        • Ponder E.
        Method for Determining the Form of Destruction of Red Cell Resistances to Single Hemolysins.
        Blood. 1948; 3: 556