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By means of the study of the survival of transfused erythrocytes an intrinsic erythrocyte abnormality was demonstrated in members of two families with atypical chronic familial hemolytic anemia.
The pattern of elimination of the patients' erythrocytes transfused into normal recipients was similar to that, in sickle cell anemia and congenital hemolytic icterus.
Normal erythrocytes transfused into these patients had normal survival except following a fulminating crisis in one child when the survival method enabled us to demonstrate a superimposed acquired extracorpuscular hemolytic disturbance.
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Received: May 25, 1950With the Technical Assistance of Linda Hoogana, M.S.
© 1950 Published by Elsevier Inc.