Research Article| Volume 36, ISSUE 4, P570-575, October 1950

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The prophylaxis and treatment of acute respiratory diseases with antihistaminic drugs

II. Prophylactic treatment with therapeutic dosage in Navy male recruits
  • The Personnel of United States Naval Medical Research Unit No. 4
    From Research Project NM 005 051.11 Research Division, Bureau of Medicine and Surgery, Navy Department, Washington, D. C., USA
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  • Author Footnotes
    ∗ United States Naval Training Center, Great Lakes, Ill. Participating in this study were CDR J. R. Seal, MC USN, Director; LT C. E. Curtis, MSC USN, Biometrician; LT. L. E. Anthony, MC USN, Clinical Coordinator; WO R. T. Goerner, Jr., HC USN Field Laboratory; R. L. Woolridge, Immunologist; B. L. Johnpeter, Bacteriologist; and other civilian and enlisted personnel. Consultants were: Thomas G. Ward, M.D., Johns Hopkins University, Baltimore, Md.; Clayton G. Loosli, M.D., and William E. Lester, M.D., the Department of Medicine, University of Chicago, Chicago, Ill.
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      Two antihistaminic drugs, in dosage within the therapeutic range for each, and a placebo were administered prophylactically to a population of 357 Navy male recruits during the period April 10 to 18, 1950. Epidemic influenza had subsided and no new cases were diagnosed during the period of study. Neither of the antihistaminic drugs demonstrated any ability to prevent the common colds which were epidemic in the population. The use of therapeutic doses before the onset of symptoms did not result in the “aborting” of colds or any important alteration in their symptomatology and duration.
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