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Research Article| Volume 36, ISSUE 4, P576-583, October 1950

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The prophylaxis and treatment of acute respiratory diseases with antihistaminic drugs

III. Treatment of minor acute respiratory infection in Navy Wave recruits
  • The Personnel of United States Naval Medical Research Unit. No. 4
    Footnotes
    Affiliations
    From Research Project NM 005 051.11 Research Division, Bureau of Medicine and Surgery, Navy Department, Washington, D. C., USA
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  • Author Footnotes
    ∗ United States Naval Training Center, Great Lakes, Ill. Participating in this study were CDR J. R. Seal, MC USN, Director; LT C. E. Curtis, MSC USN, Biometrician; LT L. E. Anthony, MC USN, Clinical Coordinator; LTJG P. J. Bartzen, MCR, Medical Officer, Wave Recruits; WO R. T. Goerner, Jr., HC USN, Field Laboratory; LT L. A. Ruffer, NC USN; LT L. Howerton, NC USNR; LTJG K. Koschin, NC USN; HM1 B. J. Daum (W) USN; R. L. Woolridge Immunologist; B. L. Johnpeter, Bacteriologist; and other civilian and enlisted personnel. Consultants were: Thomas G. Ward, M.D., Johns Hopkins University, Baltimore, Md.; Clayton G. Loosli, M.D. and William E. Lester, M.D., Department of Medicine, the University of Chicago, Chicago, Ill.
DOI:https://doi.org/10.5555/uri:pii:0022214350901545
The prophylaxis and treatment of acute respiratory diseases with antihistaminic drugs
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      Abstract

      Navy Wave recruits suffering from an acute respiratory disease clinically. classifiable as the common cold were admitted in rotation to groups receiving treatment with atropine sulfate, a placebo, and an antibhistamine drug. A few cases of influenza were included in the groups. No evidence was derived that either atropine or the antihistamine aborted colds or effected any important variations in their duration or symptomatology. The observation was made that the antihistaminic drug had an atropine-like effect on the nasal mucosa. The use of the appearance of the nasal mucosa as a criterion for “cure” in the evaluation of these drugs against colds may prove misleading.
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      Article info

      Publication history

      Received: June 19, 1950

      Footnotes

      ☆The opinions expressed herein are those of the authors and cannot be construed as reflecting the views of the Navy Department or of the Naval Service at large.

      ☆☆The use of commercially available products or preparations in connection with this project cannot be construed as indicating endorsement or approval of such products by the Naval Service or by the authors, nor as preference for one brand of antihistamine to the exclusion of other similar products on the market.

      Identification

      DOI: https://doi.org/10.5555/uri:pii:0022214350901545

      Copyright

      © 1950 Published by Elsevier Inc.

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