Research Article| Volume 36, ISSUE 4, P576-583, October 1950

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The prophylaxis and treatment of acute respiratory diseases with antihistaminic drugs

III. Treatment of minor acute respiratory infection in Navy Wave recruits
  • The Personnel of United States Naval Medical Research Unit. No. 4
    From Research Project NM 005 051.11 Research Division, Bureau of Medicine and Surgery, Navy Department, Washington, D. C., USA
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  • Author Footnotes
    ∗ United States Naval Training Center, Great Lakes, Ill. Participating in this study were CDR J. R. Seal, MC USN, Director; LT C. E. Curtis, MSC USN, Biometrician; LT L. E. Anthony, MC USN, Clinical Coordinator; LTJG P. J. Bartzen, MCR, Medical Officer, Wave Recruits; WO R. T. Goerner, Jr., HC USN, Field Laboratory; LT L. A. Ruffer, NC USN; LT L. Howerton, NC USNR; LTJG K. Koschin, NC USN; HM1 B. J. Daum (W) USN; R. L. Woolridge Immunologist; B. L. Johnpeter, Bacteriologist; and other civilian and enlisted personnel. Consultants were: Thomas G. Ward, M.D., Johns Hopkins University, Baltimore, Md.; Clayton G. Loosli, M.D. and William E. Lester, M.D., Department of Medicine, the University of Chicago, Chicago, Ill.
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      Navy Wave recruits suffering from an acute respiratory disease clinically. classifiable as the common cold were admitted in rotation to groups receiving treatment with atropine sulfate, a placebo, and an antibhistamine drug. A few cases of influenza were included in the groups. No evidence was derived that either atropine or the antihistamine aborted colds or effected any important variations in their duration or symptomatology. The observation was made that the antihistaminic drug had an atropine-like effect on the nasal mucosa. The use of the appearance of the nasal mucosa as a criterion for “cure” in the evaluation of these drugs against colds may prove misleading.
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