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Abstract
Clinical observations on ten normal volunteers and twenty-five patients with a new
anticoagulant, B.O.E.A. are reported. B.O.E.A. is chemically similar to Dicumarol;
it is administered orally and is also controlled by prothrombin times. However, it
is more soluble, more rapidly absorbed, more rapidly excreted, and less toxic than
Dicumarol. The range of initial dosage necessary to achieve a therapeutic level (arbitrarily
defined as a prothrombin time of 25 sec.) was found to be 1.2 to 1.8 grams.
Therapeutic levels were obtained within twenty-four hours of administration. The range
of the required maintenance dosage was found to be 0.3 Gm. to 0.9 gram. Fluctuation
was minimized by a divided dosage schedule.
Following cessation of therapy on a divided dosage schedule, all prothrombin times
returned to normal within twenty-four hours. No toxicity was demonstrated except for
a single episode of microscopic hematuria.
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References
- The Absorption and Biological Inactivation of the New Antithrombotic Drug Tromexan.Schweiz. med. Wchnschr. 1948; 78: 806
- A New Synthetic Anticoagulant Tromexan.Schweiz. med. Wchnschr. 1949; 79: 195
- Un nouvel anticoagulant de synthèse: l'ester éthylique de l'acide dioxycoumarinyl-acétique ou Tromexan.Revue méd. de la Suisse Rom. 1949; 69: 546
- Erfahrungen mit Tromexan, einen neuen Anticoagulans der Dicumarolreihe.Schweiz. med. Wchnschr. 1949; 79: 1010
- Clinical Tests of a New Coumarin Substance.Brit. M. J. 1949; 2: 1250
Article info
Publication history
Received:
February 3,
1950
Identification
Copyright
© 1950 Published by Elsevier Inc.
