Research Article| Volume 36, ISSUE 1, P19-22, July 1950

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Experience with the new anticoagulant, B.O.E.A

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      Clinical observations on ten normal volunteers and twenty-five patients with a new anticoagulant, B.O.E.A. are reported. B.O.E.A. is chemically similar to Dicumarol; it is administered orally and is also controlled by prothrombin times. However, it is more soluble, more rapidly absorbed, more rapidly excreted, and less toxic than Dicumarol. The range of initial dosage necessary to achieve a therapeutic level (arbitrarily defined as a prothrombin time of 25 sec.) was found to be 1.2 to 1.8 grams.
      Therapeutic levels were obtained within twenty-four hours of administration. The range of the required maintenance dosage was found to be 0.3 Gm. to 0.9 gram. Fluctuation was minimized by a divided dosage schedule.
      Following cessation of therapy on a divided dosage schedule, all prothrombin times returned to normal within twenty-four hours. No toxicity was demonstrated except for a single episode of microscopic hematuria.
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        • von Kaulla K.N.
        • Pulver R.
        The Absorption and Biological Inactivation of the New Antithrombotic Drug Tromexan.
        Schweiz. med. Wchnschr. 1948; 78: 806
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        A New Synthetic Anticoagulant Tromexan.
        Schweiz. med. Wchnschr. 1949; 79: 195
        • Bickel G.
        • Della Santa R.
        Un nouvel anticoagulant de synthèse: l'ester éthylique de l'acide dioxycoumarinyl-acétique ou Tromexan.
        Revue méd. de la Suisse Rom. 1949; 69: 546
        • Deutsch E.
        Erfahrungen mit Tromexan, einen neuen Anticoagulans der Dicumarolreihe.
        Schweiz. med. Wchnschr. 1949; 79: 1010
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        • Wright H.P.
        • Kubik M.
        Clinical Tests of a New Coumarin Substance.
        Brit. M. J. 1949; 2: 1250