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Abstract
A serial distribution study after a single intravenous injection of Fe59 was carried out in rats three days after 500 r whole body x-irradiation. Half of
the rats were irradiated with their spleens exteriorized and protected. Appropriate
controls were maintained.
The animals having protected spleens showed a time-concentration relationship of tracer
iron in the spleen which was almost identical to that of the bone marrow of control
animals. Such was not found in those animals which received the same amount of irradiation
without spleen protection.
The red cells of the spleen-protected animals showed a significant concentration of
tracer iron in contrast with those of the irradiated nonprotected animals.
The livers of the irradiated, nonprotected animals accumulated four times as much
tracer iron as the controls, but the irradiated, spleen-protected animals accumulated
only three times as much.
The bone marrow of the irradiated, nonprotected animals contained very little Fe59 at any time; yet the animals with protected spleens demonstrated the capacity to
accumulate the tracer in their marrow.
Methods are described for computing the liver iron turnover and the total body iron
content. Corresponding values are given for normal female rats of the Curtis Dunning
strain.
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References
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Article info
Publication history
Received:
March 24,
1950
Footnotes
☆This work was supported by the Atomic Energy Commission.
Identification
Copyright
© 1950 Published by Elsevier Inc.
