Research Article| Volume 41, ISSUE 5, P663-669, May 1953

Normal limits of urinary coproporphyrin excretion determined by an improved method

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      The distribution of normal values for urinary coproporphyrin excretion determined by an improved method was studied in 698 normal men and 51 normal women.
      The mean coproporphyrin excretion for men, disregarding alcohol consumption, was 189 ± 59 μg per day. There was a sequential increase in average coproporphyrin excretion as customary alcohol intake increased. Slight increments in intake resulted in distinct increases in coproporphyrin excretion.
      The lowest average value obtained in males who consumed no alcoholic beverages was 166 μg per day. The highest average value obtained in those with heavy daily alcohol consumption was 232 μg per day.
      On the basis of the frequency distributions observed an upper limit of normal was set at 300 μg per day for most cases, and a lower limit of normal at 100 μg per day. For those individuals with moderately heavy alcohol consumption the upper limit should be raised to 350 μg per day, and for those abstaining completely the limit should be lowered to 275 μg per day.
      The average coproporphyrin excretion for women (134 ± 42 μg per day) was significantly less than for men. A tentative upper limit of normal for women was set at 275 μg per day.
      For both sexes the average coproporphyrin excretion during fall was significantly greater than that during spring.
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        • Schwartz S.
        • Zieve L.
        • Watson C.J.
        An Improved Method for the Determination of Urinary Coproporphyrin and an Evaluation of Factors Influencing the Analysis.
        J. Lab. & Clin. Med. 1951; 37: 843
        • Watson C.J.
        • Hawkinson V.
        • Schwartz S.
        • Sutherland D.
        Studies of Coproporphyrin. I. The Per Diem Excretion and Isomer Distribution of Coproporphyrin in Normal Human Urine.
        J. Clin. Investigation. 1949; 28: 447
      1. Schwartz, S., Bossenmeier, I., Edmondson, P., and Keprios, M.: Unpublished data.

        • Zieve L.
        ed. 2. Ph.D. Thesis. University of Minnesota, Minneapolis1952
        • Watson C.J.
        • Larson E.A.
        The Urinary Coproporphyrins in Health and Disease.
        Physiol. Rev. 1947; 27: 478
        • Franke K.
        • Fikentscher R.
        Die Bedeutung der quantitativen Porphyrinbestimmung mit der Lumineszenzmessung für die Prüfung der Leberfunktion und für Ernährungsfragen.
        München Med. Wchnschr. 1935; 82: 171
        • Franke K.
        Klinische und lebendmikroskopische Untersuchungen der gestörten Leberfunktion. II. Untersuchungen über beginnende Leberschädigungen unter besonderer Berücksichtigung der Porphyrinausscheidung im Urin.
        Ztschr. f. klin. Med. 1936; 130: 222
        • Sutherland D.A.
        • Watson C.J.
        Studies of Coproporphyrin. VI. The Effect of Alcohol on the Per Diem Excretion and Isomer Distribution of the Urinary Coproporphyrins.
        J. Lab. & Clin. Med. 1951; 37: 29
      2. Hoffbauer, F. W., Schwartz, S., and Watson, C. J.: Studies of Urinary and Fecal Coproporphyrin Excretion in Rats. I. Results in Normals and Castrates, To be published.

        • Watson C.J.
        The Erythrocyte Coproporphyrin.
        Arch. Int. Med. 1950; 86: 797
        • Strait L.A.
        • Bierman H.R.
        • Eddy B.
        • Hrenoff M.
        • Eiler J.J.
        Relationship of Body Weight and Coproporphyrin Excretion.
        J. Appl. Physiol. 1952; 9: 699