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Research Article| Volume 41, ISSUE 5, P663-669, May 1953

Normal limits of urinary coproporphyrin excretion determined by an improved method

DOI:https://doi.org/10.5555/uri:pii:0022214353900018
Normal limits of urinary coproporphyrin excretion determined by an improved method
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      Abstract

      The distribution of normal values for urinary coproporphyrin excretion determined by an improved method was studied in 698 normal men and 51 normal women.
      The mean coproporphyrin excretion for men, disregarding alcohol consumption, was 189 ± 59 μg per day. There was a sequential increase in average coproporphyrin excretion as customary alcohol intake increased. Slight increments in intake resulted in distinct increases in coproporphyrin excretion.
      The lowest average value obtained in males who consumed no alcoholic beverages was 166 μg per day. The highest average value obtained in those with heavy daily alcohol consumption was 232 μg per day.
      On the basis of the frequency distributions observed an upper limit of normal was set at 300 μg per day for most cases, and a lower limit of normal at 100 μg per day. For those individuals with moderately heavy alcohol consumption the upper limit should be raised to 350 μg per day, and for those abstaining completely the limit should be lowered to 275 μg per day.
      The average coproporphyrin excretion for women (134 ± 42 μg per day) was significantly less than for men. A tentative upper limit of normal for women was set at 275 μg per day.
      For both sexes the average coproporphyrin excretion during fall was significantly greater than that during spring.
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      References

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        An Improved Method for the Determination of Urinary Coproporphyrin and an Evaluation of Factors Influencing the Analysis.
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      3. Schwartz, S., Bossenmeier, I., Edmondson, P., and Keprios, M.: Unpublished data.

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      Article info

      Publication history

      Received: January 3, 1953

      Footnotes

      ☆Reviewed in the Veterans Administration and published with the approval of the Chief Medical Director. The statements and conclusions published by the authors are the result of their own study and do not necessarily reflect the opinion or policy of the Veterans Administration.

      ☆☆Aided by grants from the Veterans Administration upon recommendation of the National Research Council's Committee on Veterans Medical Problems, the Surgeon-General's Office, under sponsorship of the Commission on Liver Diseases, Armed Forces Epidemiological Board and Atomic Energy Commission under contract No. AT (11-1) 100.

      Identification

      DOI: https://doi.org/10.5555/uri:pii:0022214353900018

      Copyright

      © 1953 Published by Elsevier Inc.

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