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Studies on the rate of decline of the blood sugar level calculated for the 30 to 60 minute period of the modified G.I.T.T. were carried out on ten nondiabetic individuals using the following insulin dosages: (1) 0.01 unit per kilogram, (2) 0.02 unit per kilogram, (3) 0.05 unit per kilogram, (4) 0.10 unit per kilogram, (5) 0.20 unit per kilogram, (6) 0.30 unit per kilogram. It was found that the mean rate of decline was proportional to the insulin dosage up to 0.05 unit per kilogram. Further increase in insulin dosage up to 0.30 unit per kilogram caused no further acceleration of the rate of decline. From these observations it is concluded that 0.1 unit per kilogram is probably the most satisfactory dosage for use in the modified G.I.T.T. in the estimation of insulin sensitivity.
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- The Estimation of Insulin Sensitivity by the Modified Glucose Insulin Tolerance Test.J. Lab. & Clin. Med. 1952; 39: 404-413
- Clinical Investigation Into the Effect of Intravenous Injection of Insulin.Acta Med. Scandinav. 1929; 72: 492-510
- Diabetes Mellitus; Its Differentiation Into Insulin-Sensitive and Insulin-Insensitive Types.Lancet. 1936; 1: 127-130
- Studies of Artheriovenous Differences in Blood Sugar. III. Effect of Insulin Administered Intravenously in the Postabsorptive State.J. Biol. Chem. 1949; 179: 217-233
- Insulin-Sensitive and Insulin-Insensitive Types of Diabetes Mellitus.Clin. Sc. 1939; 4: 119-155
- The Value of the Glucose Tolerance Test, the Insulin Tolerance Test and the Glucose-Insulin Tolerance Test in the Diagnosis of Endocrinologic Disorders of Glucose Metabolism.J. Clin. Endocrinol. 1941; 1: 297-306
- The Course of Blood Sugar at the Intravenous Insulin in Normal Dogs and Cats.Am. J. Physiol. 1937; 119: 531-537
- The Combination of Insulin With Tissue.Ann. New York Acad. Sc. 1951; 54: 671-683
- Photometric Adoption of Somogyi Method for Determination of Glucose.J. Biol. Chem. 1944; 153: 357-380
- Intravenous Glucose Tolerance Test.J. Clin. Investigation. 1941; 20: 507-515
- Carbohydrate Metabolism.in: University of Chicago Press, Chicago1946: 183
- Studlies of the Role of the Liver in Human Carbohydrate Metabolism by Venous Catheter Technic. II. Patients Diabetic Ketosis, Before and After the Administration of Insulin.J. Clin. Investigation. 1949; 28: 1126-1133
- The Insulin Sensitivity of Patients With Diabetes Mellitus.J. Clin. Investigation. 1950; 29: 1633-1635
- Elementary Medical Statistics.W. B. Saunders Company, Philadelphia1952
Received: October 13, 1952
© 1953 Published by Elsevier Inc.