Research Article| Volume 41, ISSUE 5, P684-689, May 1953

The effect of varying insulin dosages on the rate of decline of the blood sugar in the modified glucose insulin tolerance test

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      Studies on the rate of decline of the blood sugar level calculated for the 30 to 60 minute period of the modified G.I.T.T. were carried out on ten nondiabetic individuals using the following insulin dosages: (1) 0.01 unit per kilogram, (2) 0.02 unit per kilogram, (3) 0.05 unit per kilogram, (4) 0.10 unit per kilogram, (5) 0.20 unit per kilogram, (6) 0.30 unit per kilogram. It was found that the mean rate of decline was proportional to the insulin dosage up to 0.05 unit per kilogram. Further increase in insulin dosage up to 0.30 unit per kilogram caused no further acceleration of the rate of decline. From these observations it is concluded that 0.1 unit per kilogram is probably the most satisfactory dosage for use in the modified G.I.T.T. in the estimation of insulin sensitivity.
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