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Abstract
Nine male veterans suffering from multiple sclerosis were given ACTH by slow intravenous
drip during a ten-day period. The permeability of the “blood-CSF barrier” before,
during, and after the ACTH administration was studied by means of bromide determinations
in serum and spinal fluid. There were no significant objective clinical changes noted
during or after ACTH administration, although the drop in circulating eosinophils
showed that the patients were reacting to the hormone. The changes in serum-CSF bromide
ratios were variable and not marked during or after ACTH administration. There was
some decrease in the amount of spinal fluid protein during ACTH administration in
eight of the nine cases studied.
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References
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Article info
Publication history
Received:
December 26,
1952
Identification
Copyright
© 1953 Published by Elsevier Inc.
