Research Article| Volume 41, ISSUE 5, P754-759, May 1953

Blood cerebrospinal fluid barrier in multiple sclerosis during acth administration

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      Nine male veterans suffering from multiple sclerosis were given ACTH by slow intravenous drip during a ten-day period. The permeability of the “blood-CSF barrier” before, during, and after the ACTH administration was studied by means of bromide determinations in serum and spinal fluid. There were no significant objective clinical changes noted during or after ACTH administration, although the drop in circulating eosinophils showed that the patients were reacting to the hormone. The changes in serum-CSF bromide ratios were variable and not marked during or after ACTH administration. There was some decrease in the amount of spinal fluid protein during ACTH administration in eight of the nine cases studied.
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      1. Randt, C. T., Traeger, C. H., and Merritt, H. H.: A Clinical Study of the Effect of ACTH on Chronic Neurologic Disorders in Seven Patients, in Mote, J. R.: Proceedings of the First Clinical ACTH Conference, Philadelphia, The Blakiston Company, 595–602.

        • Glaser G.H.
        • Merritt H.H.
        Effects of Corticotropin (ACTH) and Cortisone on Disorders of the Nervous System.
        J. A. M. A. 1952; 148: 898-904
        • Broman T.
        The Permeability of the Cerebrospinal Vessels in Normal and Pathological Conditions.
        Ejnar Munksgaard, Copenhagen1949
        • Von Storch T.J.C.
        • Lawyer T.
        • Harris A.H.
        Colloidal Gold Reactions in Multiple Sclerosis.
        Arch. Neurol. & Psychiat. 1950; 64: 668
        • Prados M.
        • Strowger M.A.
        • Feindel W.
        Studies on Cerebral Edema, II. Reaction of the Brain to Exposure to Air; Physiologic Changes.
        Arch. Neurol. & Psychiat. 1945; 54: 290
        • Soffer L.J.
        • Schwartzman G.
        • Schneierson S.S.
        • Gabrilone J.L.
        Science. 1950; 111: 303
        • Walter F.K.
        Das Problem der Blut, Hirnschranke.
        Fortschr. Neurol. Psychiat. 1935; 7: 213
        • Zetterholm S.
        Blood-Spinal Fluid Permeability to Bromide in Closed Head Injuries.
        Acta Psych. Neurol. 1947;
        • Snell F.D.
        third edition. Colorimetric Methods of Analysis. 2. Van Nostrand, New York1936: 722