Research Article| Volume 41, ISSUE 5, P760-766, May 1953

Cellular changes in effusions following intracavitary administration of colloidal AU198 in human beings

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      • 1.
        1. Pleural and ascitic fluids associated with malignant neoplasms have been studied in an effort to clarify the mechanisms involved in intracavitary radiogold therapy. Following treatment, malignant cells persist in a significant proportion of cases.
      • 2.
        2. The inflammatory cellular response to the injection of the radioactive gold is quite variable.
      • 3.
        3. Phagocytes containing gold pigment are found with regularity at various intervals following therapy, being seen as early as one day and usually present during the first four to five weeks after treatment. Subsequently, they are infrequently found.
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      1. Tabern, D.: Abbott Laboratories—Personal communication.

        • Sherman A.I.
        • Bonebrake M.
        • Allen W.M.
        The Application of Radioactive Colloidal Gold in the Treatment of Pelvic Cancer.
        Am. J. Roentgenol. Oct. 1951; 65: 624-637
      2. Kniseley, R. M., and Andrews, G. A.: Pathological Changes Following Intracavitary Therapy with Colloidal Au198 Cancer, To be published.

        • Goldie H.
        • Hahn P.F.
        Distribution and Effects of Colloidal Radioactive Gold in Peritoneal Fluid Containing Free Sarcoma 37 Cells.
        in: ed. 2. Proc. Soc. Exper. Biol. & Med. 74. 1950: 638-642
      3. Andrews, G. A., Root, S. W., and Kniseley, R. M.: Metabolism and Distribution of Colloidal Gold198 Injected into Serous Cavities for Treatment of Effusions Associated with Malignant Neoplasms, Cancer, To be published.