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Abstract
A modified Lee and White method for determination of coagulation time is described
and proposed, which is believed to be more accurate and more sensitive than the methods
currently in use, and which is not overly complicated or time-consuming. The method
is designed to standardize and, insofar as is feasible, to minimize extraneous factors
which influence the coagulation of venous blood.
Application of the method in the study of normal subjects, hospitalized patients awaiting
elective surgery, and postoperative surgical patients is reported.
It was found in normal subjects that the average coagulation time by the proposed
method was twenty-six minutes, with a range of twenty to thirty-five minutes. A statistically
significant decrease in the average coagulation time in hospitalized patients awaiting
surgery was observed, and a further drop was demonstrated on the first postoperative
day.
It is emphasized that due to the multiplicity of factors which affect intravascular
clotting, no coagulation test can invariably indicate predisposition to thrombosis
or hemorrhage, but it is hoped that the proposed method will increase the probability
of predicting such occurrences.
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References
- The Coagulation Time of the Blood as Affected by Various Conditions.Arch. Int. Med. 1911; 8: 694
- A Clinical Study of the Coagulation Time of Blood.Am. J. M. Sc. 1913; 1: 495
- Platelets in the Coagulation of the Blood.Am. J. M. Sc. 1949; 217: 198
- The Evaluation of the Coagulation of the Blood.Laryngoscope. 1944; 54: 677
- Mechanism of Blood Coagulation.Am. J. Med. 1947; 3: 67
- Photoelectric Study of Some Factors Related to Blood Clotting.J. Clin. Investigation. 1946; 25: 37
- The Effect of Temperature in the Waugh-Ruddick Test for Increased Coagulability of Blood.Canad. M. A. J. 1945; 52: 185
- A Test for Increased Coagulability of Blood.Canad. M. A. J. 1944; 50: 547
- The Coagulation Time of Blood in Silicone Tubes.Am. J. M. Sc. 1949; 219: 42
- Delayed Blood Coagulation and Absence of Clot Retraction in Collodion Lined Vessels.in: ed. 2. Proc. Soc. Exper. Biol. & Med. 45. 1940: 122
- The Effect of Foreign Surfaces on Blood Coagulation.J. Clin. Investigation. 1942; 21: 241
- Influence of the Contacting Surface on the Coagulability and Anticephalin Activity of Normal and Hemophilic Plasmas.Am. J. Physiol. 1945; 143: 67
- Blood Coagulation in Leucemia and Polycythemia; Value of the Heparin Clotting Time and Clot Retraction Rate.J. Lab. & Clin. Med. 1949; 34: 1321
- A Method for Estimating the Potency of Heparin Preparations.Biochem. J. 1941; 35: 770
- A Colorimetric Method for the Standarization of Heparin.Biochem. J. 1941; 35: 776
- The Thrombo-Embolism Problem.Am. J. M. Sc. 1947; 215: 220
Article info
Publication history
Received:
November 5,
1952
Identification
Copyright
© 1953 Published by Elsevier Inc.
