Research Article| Volume 41, ISSUE 5, P767-775, May 1953

A rational approach to the problems of the coagulation time

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      A modified Lee and White method for determination of coagulation time is described and proposed, which is believed to be more accurate and more sensitive than the methods currently in use, and which is not overly complicated or time-consuming. The method is designed to standardize and, insofar as is feasible, to minimize extraneous factors which influence the coagulation of venous blood.
      Application of the method in the study of normal subjects, hospitalized patients awaiting elective surgery, and postoperative surgical patients is reported.
      It was found in normal subjects that the average coagulation time by the proposed method was twenty-six minutes, with a range of twenty to thirty-five minutes. A statistically significant decrease in the average coagulation time in hospitalized patients awaiting surgery was observed, and a further drop was demonstrated on the first postoperative day.
      It is emphasized that due to the multiplicity of factors which affect intravascular clotting, no coagulation test can invariably indicate predisposition to thrombosis or hemorrhage, but it is hoped that the proposed method will increase the probability of predicting such occurrences.
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