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The assay of streptokinase by a relative potency method is described and suggested for use. This method, when used with standardized reagents and a reference streptokinase preparation, eliminates many sources of error inherent in previous procedures. The statistical treatment of the data permits an estimate of potency to be obtained together with 95 per cent confidence limits of the error of the assay and provides means for detecting significant deviations from parallelism. The latter is useful for detecting certain interfering substances that may occur in streptokinase preparations.
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Received: January 23, 1953
© 1953 Published by Elsevier Inc.