Clinical and experimental| Volume 44, ISSUE 2, P171-176, August 1954

The hemolytic effect of primaquine, II. The natural course of the hemolytic anemia and the mechanism of its self-limited character

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      The administration of primaquine to six drug-sensitive recipients in daily doses of 30 mg. base resulted in acute hemolysis followed by complete hematological recovery, although drug administration was continued. Studies with Cr51-labeled erythrocytes demonstrated an abrupt decrease in the rate of hemolysis after about a week of drug administration. This was confirmed by clearing of the urine and a return of reticulocyte counts to lower levels. The self-limitation of the hemolysis was shown to he due to a change in the reactivity of the red cell population. The capacity of drug-sensitive volunteers to hemolyze known primaquine-sensitive cells was not altered during long-term drug administration. Prolonged administration of 30 mg. primaquine base daily (50 to 135 days) to six men produced no other evidence of toxicity.
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