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Abstract
The administration of primaquine to six drug-sensitive recipients in daily doses of
30 mg. base resulted in acute hemolysis followed by complete hematological recovery,
although drug administration was continued. Studies with Cr51-labeled erythrocytes demonstrated an abrupt decrease in the rate of hemolysis after
about a week of drug administration. This was confirmed by clearing of the urine and
a return of reticulocyte counts to lower levels. The self-limitation of the hemolysis
was shown to he due to a change in the reactivity of the red cell population. The
capacity of drug-sensitive volunteers to hemolyze known primaquine-sensitive cells
was not altered during long-term drug administration. Prolonged administration of
30 mg. primaquine base daily (50 to 135 days) to six men produced no other evidence
of toxicity.
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References
- Status of Primaquine. 4. Toxicity of Primaquine in Negroes.J. A. M. A. 1952; 149: 1568-1570
- The Hemolytic Effect of Primaquine. I. The Localization of the Drug-induced Hemolytic Defect in Primaquine-sensitive Individuals.J. Lab. & Clin. Med. 1954; 43: 303-309
- Radioactive Sodium Chromate for the Study of Survival of Red Blood Cells. 1. The Effect of Radioactive Sodium Chromate on Red Cells.J. Lab. & Clin. Med. 1953; 42: 358-367
Article info
Publication history
Received:
April 23,
1954
Footnotes
☆This investigation was carried out under contract number DA-49-007-MD-20 between the Office of the Surgeon General, United States Army and the Department of Medicine of the University of Chicago.
☆☆This work was further aided by the participation of Army Medical Officers assigned to the project by the Surgeon General of the United States Army.
★The investigations reported in this paper would not have been possible except for the cooperation of the inmates and the administrative staff of Stateville Penitentiary.
Identification
Copyright
© 1954 Published by Elsevier Inc.
