This paper is only available as a PDF. To read, Please Download here.
Abstract
Acid-fast organisms differing from known human or bovine tuberculosis strains have
been isolated from eighty-eight patients. Although some appear to be intimately associated
with pulmonary disease in man, none was virulent for guinea pigs inoculated with 1
mg. of organisms.
It was possible to divide the organisms tentatively into three groups on the basis
of colonial characteristics. Two of the groups (I and III) were found to be virulent
for mice while the other was not.
The taxonomic identity of the organisms described has not yet been established. Colonial
and growth characteristics of the three groups are described. Certain of the strains
show some resemblance to avian or vole bacilli.
The organisms displaying mouse virulence are characterized by repeated occurrence
over long periods of time iii sputa from the same patients, none of whom were found
to have concurrent infection with M. tuberculosis. Seven of these strains were found directly in diseased human lung tissue. Twenty-four
of these strains were tested for virulence in mice, and all caused lung lesions. On
the other hand, seventeen strains of Group II showed no virulence for mice and were
not as consistently associated with human disease. These organisms were found in lower
concentration in original specimens and a greater proportion of them was isolated
from gastric washings. Furthermore, several were from patients harboring typical tubercle
bacilli as well.
In the light of these findings, discard of an acid-fast organism isolated from a patient
with pulmonary disease because it fails to fit the cultural or virulence pattern of
M. tuberculosis does not appear justified.
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Translational ResearchAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Diagnostic and Experimental Methods in Tuberculosis. ed. 2. Charles C Thomas, Springfield1952: 373
- Atypical Tubercle Bacilli in Human and Animal Tuberculosis With Special Reference to Those Occurring in Lupus.Tubercle. 1924; 5: 569
- An Acid-fast Bacillus Obtained From a Pustular Eruption.Brit. M. J. 1918; 2: 158
- Studies on the Types of Tubercle Bacillus Isolated From Man. II. Strains of Attenuated Virulence. III. Transformation of Some Atypical Strains, Non-pathogenic for Rabbits, Into Bovine Types Through Rabbit Passages.Acta tuberc. scandinav. 1936; 10: 217
- The Types of Tubercle Bacilli in Human Tuberculosis.Am. Rev. Tuberc. 1927; 15: 225
- On an Isolated Tuberculoid Form of Skin Granuloma Caused by Atypical Acid-Fast Bacilli.Acta path, et microbiol. scandinav. 1944; : 574
- Possible Tuberculous Skin Infection From a Swimming Pool.in: Report of Four Cases. Acta dermat.-venereol. 31. 1951: 147
- Collected Cases of Inoculation Lupus Vulgaris.Acta dermat.venereol. 1951; 31: 194
- A New Mycobacterial Infection in Man; Clinical Aspects.J. Path. & Bact. 1948; 60: 93
- A New Mycobacterial Infection in Man; Experimental Investigations in Laboratory Animals; Cultivation of the New Mycobacterium.J. Path. & Bact. 1948; 60: 102
- A New Mycobacterial Infection in Man; Experimental Investigations in Laboratory Animals; Cultivation of the New Mycobacterium.J. Path. & Bact. 1948; 60: 116
- Studies on Mycobacterium ulcerans. I. Serological Relationship to Other Mycobacteria. II. Cross Reactivity in Guinea Pigs Sensitized With M. ulcerans and Other Mycobacteria, Australian.J. Exper. Biol. & Med. Sc. 1952; 30: 1
- Studies on Mycobacterium ulcerans. I. Serological Relationship to Other Mycobacteria. II. Cross Reactivity in Guinea Pigs Sensitized With M. ulcerans and Other Mycobacteria, Australian.J. Exper. Biol. & Med. Sc. 1952; 30: 11
- A New Type of Pathogenic Mycobacterium.Nature. 1951; 168: 826
- An Unusual Acid-Fast Infection of the Knee With Subcutaneous, Abscess-like Lesions of the Gluteal Region.in: Report of a Case With a Study of the Organism Mycobacterium abscessus, n. sp. J. Invest. Derm. 20. 1953: 133
- Saprophytic Mycobacterial Lung Infection.J. Path. & Bact. 1953; 65: 239
- Mycobacterium (sp.?) Ryan Strain Isolated From Pleural Exudate.J. Infect. Dis. 1931; 49: 399
- Study of Acid-Fast Organisms Other Than Mammalian Tubercle Bacilli Isolated From Disease in Man.Tubercle. 1933; 14: 337
- An Unusual Mycobacterium Isolated From Sputum of a Man Suffering From Pulmonary Disease of Long Duration.Am. Rev. Tuberc. 1943; 48: 82
- Human Infection With Atypical Acid-fast Organisms.in: Report of Two Cases With Pathological Findings. Am. J. Clin. Path. 23. 1953: 363
- Pulmonary Granuloma Caused by Atypical Mycobacterium.in: Case Report, Trans. 13th VA-Army-Navy Conference on Chemotherapy of Tuberculosis, St. LouisFeb. 1954 (To be published.)
- Tuberculosis Evaluation Laboratory Methods.(mimeographed) Public Health Service, Tuberculosis Control Division and Communicable Disease Center, Atlanta, GaNov. 1, 1948
Buhler, V. B.: Personal communication.
Owen, B.: Personal communication.
- Certain Non-pathogenic Mycobacteria as a Source of Error in Diagnosis and Drug Susceptibility Tests.Am. Rev. Tuberc. 1953; 68: 557
- Non-pathogenic Acid-Fast Bacilli: A Case of Chronic Pneumonitis Associated With a Non-pathogenic Acid-Fast Bacillus.Am. Rev. Tuberc. 1942; 45: 756
- Chronic Induration Pneumonia Resulting From Cardiospasm.J. Lab. & Clin. Med. 1943; 28: 1591
- Atypical Acid-Fast Organisms. III. Chromogenic Acid-Fast Bacilli From Human Beings. IV. Smooth-Growing Tubercle Bacilli.Am. Rev. Tuberc. 1935; 32: 424
- Pulmonary Disease Secondary to Cardiospasm With Acid-Fast Bacilli in the Sputum.Dis. Chest. 1946; 12: 232
- An Acid-Fast Other Than Koch's Bacillus Cultivated From Sputum.Tubercle. 1933; 15: 49
- Observations on the “M” Strain of Acid-Fast Bacilli.Tubercle. 1933; 15: 53
- Dissociation of Two Unusual Organisms Isolated From Human Sources.J. Infect. Dis. 1936; 58: 247
- An Unidentified Acid-Fast Bacillus (Mycobacterium sp., strain Glasgow) Found in Human Sputum and Lung Disease.J. Path. & Bact. 1953; 65: 253
- Chromogenic Acid-Fast Bacilli From Human Sources; I. Cultural Studies; II. Pathological Studies; III. Hypersensitivity Studies.Am. Rev. Tuberc. 1952; 65: 278
- Chromogenic Acid-Fast Bacilli From Human Sources; I. Cultural Studies; II. Pathological Studies; III. Hypersensitivity Studies.Am. Rev. Tuberc. 1952; 65: 289
- Chromogenic Acid-Fast Bacilli From Human Sources; I. Cultural Studies; II. Pathological Studies; III. Hypersensitivity Studies.Am. Rev. Tuberc. 1952; 65: 302
- Differences Between Tubercle Bacilli and Other Acid-Fast Bacilli From Human Sources.Acta tuberc. scandinav. 1953; 28: 340
Article info
Publication history
Received:
April 27,
1954
Identification
Copyright
© 1954 Published by Elsevier Inc.
