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Data are presented indicating the association of marked elevations in unit leukocyte alkaline phosphatase in a wide variety of “stress” conditions including various disease states, infection, trauma, pregnancy, and operative procedures. The phenomenon is reproduced by substantial doses of ACTH Gel, but is not to the same extent or consistency by cortisone acetate and hydrocortisone. In certain types of “stress” such as rheumatoid arthritis, rheumatic fever, and lupus erythematosus, elevations above the normal range are uncommonly seen even in the presence of severe illness. The possible relations of leukocyte alkaline phosphatase act ivity to pituitary and or adrinal cortical activity are discussed.
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Received: May 7, 1954
☆This investigation was supported by research grant Number H1069 (C3R) from the National Cancer Institute of the National Institutes of Health, Public Health Service, and by a grant from Parke, Davis & Company, Detroit, Mich.
© 1954 Published by Elsevier Inc.