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Abstract
Data are presented indicating the association of marked elevations in unit leukocyte
alkaline phosphatase in a wide variety of “stress” conditions including various disease
states, infection, trauma, pregnancy, and operative procedures. The phenomenon is
reproduced by substantial doses of ACTH Gel, but is not to the same extent or consistency
by cortisone acetate and hydrocortisone. In certain types of “stress” such as rheumatoid
arthritis, rheumatic fever, and lupus erythematosus, elevations above the normal range
are uncommonly seen even in the presence of severe illness. The possible relations
of leukocyte alkaline phosphatase act ivity to pituitary and or adrinal cortical activity
are discussed.
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References
- Biochemical Studies on Leukocytes. I. Phosphatase Activity in Health, Leukocytosis and Myelocytic Leukemia.J. Lab. & Clin. Med. 1951; 38: 39
- Biochemical Studies on Leukocytes. II. Phosphatase Activity in Chronic Lymphocytic Leucemia, Acute Leucemia, and Miscellaneous Hematologic Conditions.J. Lab. & Clin. Med. 1951; 38: 245
- Biochemical Studies in Chronic Myelocytic Leukemia, Polycythemia Vera and Other Idiopathic Myeloproliferative Disorders.Blood. 1952; 7: 959
- Alkaline Phosphatase Activity in Blood and Bone Marrow Cells.J. Lab. & Clin. Med. 1946; 31: 1
- The Effect of Crystalline Adrenal Cortical Steroids, dl-Thyroxine and Epenephrine on the Alkaline and Acid Phosphatases and Arginase of the Liver and Kidney of the Normal Adult Rat.J. Biol. Chem. 1948; 176: 243
- Adrenal Cortex and Carbohydrate Phosphorylation.in: Colloquia on Endocrinology. J. & A. Churchill, Ltd, London1953: 152-165
Article info
Publication history
Received:
May 7,
1954
Footnotes
☆This investigation was supported by research grant Number H1069 (C3R) from the National Cancer Institute of the National Institutes of Health, Public Health Service, and by a grant from Parke, Davis & Company, Detroit, Mich.
Identification
Copyright
© 1954 Published by Elsevier Inc.
