This paper is only available as a PDF. To read, Please Download here.
Antistreptolysin “O” and gamma globulin levels decrease most rapidly in patients with rheumatic fever who receive ACTH. Although the difference between the cortisone-treated and aspirin-treated groups was not statistically significant, cortisone appeared to decrease the elevated antistreptolysin and gamma globulin concentrations more rapidly than aspirin.
Following the cessation of treatment in all three groups, there were slight increases in the average gamma globulin concentration without similar increases in the average antistreptolysin “O” titer.
To read this article in full you will need to make a payment
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:Subscribe to Translational Research
Already a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
- Thomas L. Rheumatic Fever, A Symposium. University of Minnesota Press, Minneapolis1952: 136
- Quantitative Antistreptokinase Studies in Patients Infected With Group A Hemolytic Streptococci; Comparison With Serum Antistreptolysin and Gamma Globulin Levels With Special Reference to the Occur rence of Rheumatic Fever.J. Clin. Invest. 1948; 27: 425-434
- Mote J.R. Proceedings of the First Clinical ACTH Conference. The Blakiston Co, Philadelphia1950: 405
- Reappearance of Abnormal Laboratory Findings in Rheumatic Patients Following Withdrawal of ACTH or Cortisone.Am. J. M. Sc. 1951; 222 (With Special Reference to C-Reactive Protein): 516-522
- Observations on the Physiologic Effects of Cortisone and ACTH in Man.Arch. Int. Med. 1950; 85: 199-258
- Comparative Effects of Aspirin, ACTH and Cortisone on the Acute Course of Rheumatic Fever in Young Male Adults.Am. J. Med. 1954; 16: 168-180
- Varying hemolytic and Constant Combining Capacity of Streptolysins; Influence on Testing for Antistreptolysins.J. Exper. Med. 1933; 58: 277-287
- Application of Turbidimetric Methods for Estimation of Gamma Globulin and Total Lipid to the Study of Patients With Liver Disease.Gastroenterology. 1948; 11: 499-507
- The Effect of Cortisone and Adrenocorticotrophic Hormone on the Concentration of Circulating Antibody.J. Exper. Med. 1951; 93: 37-48
Received: May 8, 1954
☆This investigation was conducted under the sponsorship of the Commission on Acute Respiratory Diseases and the Commission on Streptococcal Diseases, Armed Forces Epidemiological Board, and was supported by the Offices of the Surgeons General, Departments of the Army and Air Force, Washington, D. C.
© 1954 Published by Elsevier Inc.