This paper is only available as a PDF. To read, Please Download here.
Erythrocytes from two dogs were labeled with about 100 μc of Cr51 (sodium chromate) and were returned to the blood of the dogs. Portions of blood withdrawn later were placed in each dog's stomach and the subsequent radioactivity of the feces was determined. By comparing this with the radioactivity of the blood, it was possible to express the amount of Cr51 in the feces as the equivalent of circulating blood in milliliters. The amount of Cr51 recovered paralleled closely the amount contained in the blood administered to the dogs.
Additional studies on dogs and rats gave little indication of significant transfer of Cr51 from labeled erythrocytes between the blood stream and the intestine.
To read this article in full you will need to make a payment
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:Subscribe to Translational Research
Already a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
- The Tagging of Red Cells and Plasma Proteins With Radioactive Chromium.J. Clin. Invest. 1950; 29: 1604-1613
- Distribution of Iodide Between Cells and Plasma as Measured by Means of Radioactive Iodide.J. Biol. Chem. 1953; 200: 111-116
- The Determination of Plasma Volume in Man With Radioactive Chromic Chloride.J. Clin. Invest. 1953; 32: 991-999
- Distribution of Radioactivity Following Intravenous Administration of Trivalent Chromium 51 in the Rat and Rabbit.in: Proc. Soc. Exper. Biol. & Med. 81. 1952: 490-492
- Metabolism of Cr51 by Animals as Influenced by Chemical State.in: Proc. Soc. Exper. Biol. & Med. 34. 1953: 610-615
- Determination of the Circulating Red Cell Volume in Man by Radioactive Chromium.J. Clin. Invest. 1950; 29: 1614-1619
- Radioactive Sodium Chromate for the Study of Survival of Red Blood Cells. II. The Rate of Hemolysis in Certain Hematologic Disorders.J. Lab. & Clin. Med. 1953; 42: 368-376
- The Use of Radioactive Chromium 51 as an Erythrocyte Tagging Agent for the Determination of Red Cell Survival in Vivo.J. Clin. Invest. 1953; 32: 1260-1276
- The Simultaneous Determination of Red Cell Mass and Plasma Volume in Man With Radioactive Sodium Chromate and Chromic Chloride.J. Clin. Invest. 1953; 32: 1000-1004
- The Preparation of Chromium-51 of High Specific Activity.J. Chem. Physics. 1953; 21: 1686-1687
- Radioactive Sodium Chromate for the Study of Survival of Red Blood Cells. I. The Effect of Radioactive Sodium Chromate on Red Cells.J. Lab. & Clin. Med. 1953; 42: 358-367
- Estimation of Blood Loss in Hookworm Infestation With Fe59: Preliminary Report.Science. 1954; 119: 412-413
Received: April 22, 1964
☆The Mayo Foundation is a part of the Graduate School of the University of Minnesota.
© 1954 Published by Elsevier Inc.