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Clinical and experimental| Volume 44, ISSUE 2, P238-245, August 1954

Radiochromium-labeled erythrocytes for the detection of gastrointestinal hemorrhage

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      Abstract

      Erythrocytes from two dogs were labeled with about 100 μc of Cr51 (sodium chromate) and were returned to the blood of the dogs. Portions of blood withdrawn later were placed in each dog's stomach and the subsequent radioactivity of the feces was determined. By comparing this with the radioactivity of the blood, it was possible to express the amount of Cr51 in the feces as the equivalent of circulating blood in milliliters. The amount of Cr51 recovered paralleled closely the amount contained in the blood administered to the dogs.
      Additional studies on dogs and rats gave little indication of significant transfer of Cr51 from labeled erythrocytes between the blood stream and the intestine.
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