Advertisement
Translational Research
Advanced searchSave search
Clinical and experimental| Volume 44, ISSUE 2, P261-272, August 1954

Studies on recurrent aphthae: Evidence that herpes simplex is not the etiological agent, with further observations on the immune responses in herpetic infections

DOI:https://doi.org/10.5555/uri:pii:0022214354902188
Studies on recurrent aphthae: Evidence that herpes simplex is not the etiological agent, with further observations on the immune responses in herpetic infections
Previous ArticleFat emulsions as caloric supplements in parenteral nutrition, with particular reference to amino acid utilization
Next ArticleJaundice and xanthochromia of the spinal fluid
      This paper is only available as a PDF. To read, Please Download here.

      Abstract

      One hundred and one sera from sixty-two subjects with histories of recurrent aphthae, herpetic infection, or both, were examined for antibodies against herpes simplex by means of the complement fixation and/or virus neutralization techniques. In addition, nineteen of the subjects were skin tested with a non-viral herpes antigen prepared from infected egg fluids.
      Forty, or 68 per cent, of fifty-nine subjects tested were found to have herpes complement-fixing antibodies. The positive group included five patients with questionable herpetic histories and ten with no knowledge of past herpetic infection, thus re-emphasizing the frequency of mild and subclinical infection with this virus.
      Subjects with herpes complement-fixing antibodies show the same variation in serum titers as found in other infectious diseases.
      The incidence of herpes complement-fixing antibodies in subjects with recurrent aphthae was not increased as compared to that of a control group with no history of this disorder.
      Sera negative for herpes antibodies by complement fixation may occasionally contain neutralizing antibodies against this virus.
      Tests with a soluble herpes skin-test antigen prepared in eggs revealed that while the presence of neutralizing antibodies against herpes was associated with a positive skin test their absence was not always associated with a negative test.
      Of thirty patients with recurrent aphthae, eleven had no demonstrable antibodies against herpes simplex. It is noteworthy that seven of these eleven patients were skin tested with herpes antigen and five failed to react. The same seven patients developed recurrences of their lesions while under study. None showed a rise in herpes antibodies during convalescence from this disorder. These findings, together with the fact that the lesions of recurrent aphthae are pathologically inconsistent with herpetic infection, make a herpetic etiology for this disorder unlikely.
      Inapparent herpetic infection may explain the occasional reported recovery of herpes simplex from patients with recurrent aphthae.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Translational Research
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Register: Create an account
      Institutional Access: Sign in to ScienceDirect

      References

        • Scott T.F.M.
        • Steigman A.J.
        • Convey H.T.
        Acute Infectious Gingivostomatitis: Etiology, Epidemiology, and Clinical Picture of Common Disorder Caused by Virus of Herpes Simplex.
        J. A. M. A. 1941; 117: 999-1005
        • Ziskin D.
        • Holden M.
        Acute Herpetic Gingivostomatitis.
        in: Report of Fifteen Cases. ed. 4. J. Am. Dent. A. 30. 1943: 1697-1705
        • Kilbourne E.D.
        • Horsfall Jr., F.L.
        Primary Herpes Samplex Virus Infection of the Adult.
        Arch. Int. Med. 1951; 88: 495-502
        • Rosenstein S.N.
        • Ziskin D.
        Etiology and Treatment of Recurrent Oral Aphthae.
        J. Dent. Res. 1942; 21: 335-336
        • Dodd K.
        • Ruchman I.
        Herpes Simplex Virus Not the Etiologic Agent of Recurrent Stomatitis.
        Pediatrics. 1950; 5: 883-887
        • Blank H.
        • Burgoon C.F.
        • Coriell L.L.
        • Scott T.F.M.
        Recurrent Aphthous Ulcers, Correspondence.
        J. A. M. A. 1950; 142: 125-126

      7. Losch, P. K.: Personal communication.

        • Fulton F.
        • Dumbell K.R.
        The Serological Comparison of Strains of Influenza Virus.
        J. Gen. Microbiol. 1949; 3: 97-111
        • Svedmyr A.
        • Enders J.F.
        • Holloway A.
        Complement Fixation With Brunhilde and Lansing Poliomyelitis Viruses Propagated in Tissue Culture.
        in: ed. 4. Proc. Soc. Exper. Biol. & Med. 79. 1952: 296-300
        • Svedmyr A.
        • Enders J.F.
        • Holloway A.
        Complement Fixation With the Three Types of Poliomyelitis Viruses Propagated in Tissue Culture.
        Am. J. Hyg. 1953; 57: 60-70
        • Gajdusek D.C.
        • Robbins M.L.
        • Robbins F.C.
        Diagnosis of Herpes Simplex Infections by the Complement Fixation Test.
        J. A. M. A. 1952; 149: 235-240

      12. Enders, J. F., Robbins, F. C., and Kibrick, S.: Unpublished data.

        • Stulberg C.S.
        • Schapira R.
        Virus Growth in Tissue Culture Fibroblasts. I. Influenza A and Herpes Simplex Viruses.
        J. Immunol. 1953; 70: 51-59
        • Robbins F.C.
        • Weller T.H.
        • Enders J.F.
        Studies on the Cultivation of Poliomyelitis Viruses in Tissue Culture. II. The Propagation of the Poliomyelitis Viruses in Roller Tube Cultures of Various Human Tissues.
        J. Immunol. 1952; 69: 673-694
        • Jawetz E.
        • Coleman V.
        • Allende M.F.
        Studies on Herpes Simplex Virus. II. A Soluble Antigen of Herpes Virus Possessing Skin-Reactive Properties.
        J. Immunol. 1951; 67: 197-205
        • Buddingh G.J.
        • Schrum D.I.
        • Lanier J.C.
        • Guidry D.J.
        Studies of the Natural History of Herpes Simplex Infections.
        Pediatrics. 1953; 11: 595-610
        • Burnet F.M.
        • Lush D.
        Herpes Simplex: Studies on the Antibody Content of Human Sera.
        Lancet. 1939; 1: 629-631
        • Scott T.F.M.
        • Coriell L.
        • Blank H.
        • Burgoon C.F.
        Some Comments on Herpetic Infection in Children With Special Emphasis on Unusual Clinical Manifestations.
        J. Pediat. 1952; 41: 835-843
        • Burnet F.M.
        • Lush D.
        The Inactivation of Herpes Virus by Immune Sera: Experiments Using the Chorio-Allantole Membrane Technique.
        J. Path. & Bact. 1939; 48: 275-286
        • Burnet F.M.
        • Williams S.W.
        Herpes Simplex: New Point of View.
        M. J. Australia. 1939; 1: 637-642
        • Burnet F.M.
        Virus as Organism.
        in: Harvard University Press, Cambridge1945: 47-56
        • Jawetz E.
        • Coleman V.R.
        Studies on Herpes Simplex Virus. III. The Neutralization of Egg-Adapted Herpes Virus by Human Sera in Ovo.
        J. Immunol. 1952; 68: 645-653
        • Jawetz E.
        • Allende M.F.
        • Coleman V.R.
        Studies on Herpes Simplex Virus. IV. The Level of Neutralizing Antibodies in Human Sera.
        J. Immunol. 1952; 68: 655-662
        • Rose H.M.
        Differences in the Capacity of Human Serums to Neutralize Herpes Simplex Virus.
        J. Immunol. 1952; 68: 687-691
        • Wenner H.A.
        Complications of Infantile Eczema Caused by the Virus of Herpes Simplex.
        Am. J. Dis. Child. 1944; 67: 247-264
        • Hayward M.E.
        Serological Studies With Herpes Simplex Virus.
        Brit. J. Exper. Pathol. 1949; 30: 520-529
        • Hayward M.E.
        Serological Diagnosis of Herpes Simplex Infections.
        Lancet. 1950; 1: 856-858
        • Dudgeon J.A.
        A Complement Fixation Test for Herpes Simplex Infections.
        J. Clin. Path. 1950; 3: 239-247
        • Holzel A.
        • Feldman G.V.
        • Tobin O'H.
        • Harper J.
        Herpes Simplex: A Study of Complement Fixing Antibodies at Different Ages.
        Acta Paediat. 1953; 42: 206-214
        • Nagler F.P.O.
        A Herpes Skin Test Reagent From Amniotic Fluid, Austral.
        J. Exp. Biol. and M. Sc. 1946; 24: 103-105
        • Sheva G.M.
        • Robbins M.L.
        Antigenic Relationships Among Strains of Herpes Simplex Virus.
        in: ed. 4. Bact. Proc. San Francisco. M22. 1953: 49

      32. Enders, J. F.: Personal communication.

      Article info

      Publication history

      Received: April 5, 1954

      Identification

      DOI: https://doi.org/10.5555/uri:pii:0022214354902188

      Copyright

      © 1954 Published by Elsevier Inc.

      ScienceDirect

      Access this article on ScienceDirect
      We use cookies to help provide and enhance our service and tailor content. To update your cookie settings, please visit the for this site.
      Copyright © 2023 Elsevier Inc. except certain content provided by third parties. The content on this site is intended for healthcare professionals.


      RELX