Research Article| Volume 44, ISSUE 2, P292-300, August 1954

Paper chromatography applied to the detection of opium alkaloids in urine and tissues

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      Nine opium alkaloids and the morphine substitute, meperidine, have been subjected to paper chromatography and their Rf values determined, using various developing solvents and buffered papers.
      A method employing paper chromatography is described which enables the detection of minute amounts of morphine in urine and tissues.
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        • Munier R.
        • Macheboeuf M.
        Microchromatographie de partage des alcaloides et de diverses bases azotées biologiques.
        Bull. Soc. chim. biol. 1949; 31: 1144-1162
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        Relationship of the Chemical Structure of Morphine Derivatives to Their Urinary Excretion in Free and Bound Forms.
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        Note on the In Vitro Inactivation of Morphine by Liver.
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        The Effect of Prolonged Morphine Administration on the In Vitro Conjugation of Morphine by Rats.
        J. Pharmacol. & Exper. Therap. 1952; 104: 11-19
      1. Anal. Ed. The Analysis of Heroin, Bulletin on Narcotics. Vol. V. United Nations Department of Social Affairs, New York1953: 28 (No. 2)