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Research Article| Volume 63, ISSUE 1, P5-13, January 1964

Comparisons of serologic and febrile responses in humans to vaccination with influenza A viruses or their hemagglutinins

  • Fred M. Davenport
    Affiliations
    From the Department of Epidemiology and Virus Laboratory, School of Public Health, University of Michigan Ann Arbor U.S.A.

    From the Research Department, Parke, Davis and Company Ann Arbor U.S.A.

    From the Detroit City Health Department Detroit, Mich. U.S.A.
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  • Albert V. Hennessy
    Affiliations
    From the Department of Epidemiology and Virus Laboratory, School of Public Health, University of Michigan Ann Arbor U.S.A.

    From the Research Department, Parke, Davis and Company Ann Arbor U.S.A.

    From the Detroit City Health Department Detroit, Mich. U.S.A.
    Search for articles by this author
  • Frank M. Brandon
    Affiliations
    From the Department of Epidemiology and Virus Laboratory, School of Public Health, University of Michigan Ann Arbor U.S.A.

    From the Research Department, Parke, Davis and Company Ann Arbor U.S.A.

    From the Detroit City Health Department Detroit, Mich. U.S.A.
    Search for articles by this author
  • Robert G. Webster
    Affiliations
    From the Department of Epidemiology and Virus Laboratory, School of Public Health, University of Michigan Ann Arbor U.S.A.

    From the Research Department, Parke, Davis and Company Ann Arbor U.S.A.

    From the Detroit City Health Department Detroit, Mich. U.S.A.
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  • C.Dale Barrett Jr.
    Affiliations
    From the Department of Epidemiology and Virus Laboratory, School of Public Health, University of Michigan Ann Arbor U.S.A.

    From the Research Department, Parke, Davis and Company Ann Arbor U.S.A.

    From the Detroit City Health Department Detroit, Mich. U.S.A.
    Search for articles by this author
  • Glen O. Lease
    Affiliations
    From the Department of Epidemiology and Virus Laboratory, School of Public Health, University of Michigan Ann Arbor U.S.A.

    From the Research Department, Parke, Davis and Company Ann Arbor U.S.A.

    From the Detroit City Health Department Detroit, Mich. U.S.A.
    Search for articles by this author
DOI:https://doi.org/10.5555/uri:pii:0022214364900034
Comparisons of serologic and febrile responses in humans to vaccination with influenza A viruses or their hemagglutinins
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      Abstract

      Monovalent influenza virus vaccines were prepared from 3 strains of influenza A viruses. Concentrates were processed to yield either intact influenza virus vaccines or vaccines composed of the isolated hemagglutinins liberated by ether treatment and further purified by chemical and physical methods. Each type of vaccine was made from a single pool of virus per strain. Each vaccine induced equivalent hemagglutination-inhibiting antibody levels in children and adults. Approximately equal levels of neutralizing antibodies were observed to develop in the sera of children given either intact virus or isolated hemagglutinin vaccines. The isolated hemagglutinin vaccines failed to induce febrile responses in children, while the same or lower doses of intact virus vaccines were clearly pyrogenic.
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      References

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      Article info

      Publication history

      Accepted: September 23, 1963
      Received: August 9, 1963

      Footnotes

      ☆This investigation was conducted under the auspices of the Commission on Influenza, Armed Forces Epidemiological Board. The work at the University of Michigan was supported by the Office of the Surgeon General, United States Army, Washington, D. C.

      Identification

      DOI: https://doi.org/10.5555/uri:pii:0022214364900034

      Copyright

      © 1964 Published by Elsevier Inc.

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