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The ability of pharyngeal microorganisms to inhibit the action of penicillin on group A streptococci in vitro has been measured. By this method, inhibition of penicillin action upon sensitive group A streptococci was demonstrated by microbial end products in 15 per cent of patients with streptococcal pharyngitis and nonstreptococcal respiratory disease and of normal control subjects. Penicillin inhibition by such pharyngeal flora was found in a higher proportion of cases during therapy than prior to and after the end of treatment in patients who were cured. The presence of penicillin-inhibiting organisms by this in vitro test was significantly higher in the pharyngeal flora of patients who developed streptococcal relapses after initial therapy. The organism most frequently associated with this phenomenon was Staphylococcus aureus.
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- Penicillin in the Treatment of Streptococcal Infections. Comparison of Effectiveness of Five Different Oral and One Parenteral Form.New England J. Med. 1958; 259: 57
- Streptococcal Bacteriostatic Antibody in Patients Treated With Penicillin.in: ed. 5. Proc. Soc. Exper. Biol. & Med. 78. 1951: 106
- Studies on Prevention of Rheumatic Fever: Effect of Time of Initiation of Treatment of Streptococcal Infections on Immune Response of Host.J. Clin. Invest. 1953; 32: 630
- Prevention of Rheumatic Fever. Treatment of the Preceding Streptococcal Infection.J. A. M. A. 1950; 143: 151
- Attack Rates of Streptococcal Pharyngitis, Rheumatic Fever and Glomerulonephritis in the General Population.New England J. Med. 1963; 268: 687
- Antibiotics in the Treatment of Acute Hemolytic Streptococcal Pharyngitis: Factors Influencing the Results.Pediatrics. 1960; 25: 37
- Comparison of Intramuscular and Oral Benzathine Penicillin G in Treatment of Streptococcal Infections in Children.J. Pediat. 1957; 51: 157
- A Controlled Study of Beta Hemolytic Streptococcal Infections in Rheumatic Families.Am. J. Med. 1958; 25: 825
- Penicillinase Producing Staphylococci Interfering With Penicillin Treatment in Scarlet Fever.Acta path. et microbiol. scandinav. 1956; : 127
- Antagonistic Effect of Penicillinase-Producing Staphylococcus on Penicillin Therapy of a Streptococcal Infection.Am. J. Med. Sc. 1962; 243: 582
- Staphylococcal Antagonism to Penicillin G Therapy of Hemolytic Streptococcal Pharyngeal Infection: Effect of Oxacillin.Pediatrics. 1963; 31: 463
- Typing Group A Hemolytic Streptococci by M Precipitin Reactions in Capillary Pipettes.J. Exper. Med. 1943; 78: 127
- Penicillin Resistant Staphylococci.in: ed. 5. Proc. Soc. Exper. Biol. & Med. 6. 1945: 55
- The Nasal Carrier of Staphylococci Among Children of a Rural Community.J. A. M. A. 1963; 183: 1063
- Erythromycin Propionate and Potassium Penicillin V in the Treatment of Group A Streptococcal Pharyngitis.Pediatrics. 1963; 31: 22
Accepted: September 6, 1963
Received: July 10, 1963With the technical assistance of LOIS MISHCON
☆Aided in part by grants from the New York Heart Association and Eli Lilly & Company.
☆Presented in part at the American Heart Association Annual Meeting, St. Louis, Mo. October 1960.
© 1964 Published by Elsevier Inc.