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Abstract
The ability of pharyngeal microorganisms to inhibit the action of penicillin on group
A streptococci in vitro has been measured. By this method, inhibition of penicillin
action upon sensitive group A streptococci was demonstrated by microbial end products
in 15 per cent of patients with streptococcal pharyngitis and nonstreptococcal respiratory
disease and of normal control subjects. Penicillin inhibition by such pharyngeal flora
was found in a higher proportion of cases during therapy than prior to and after the
end of treatment in patients who were cured. The presence of penicillin-inhibiting
organisms by this in vitro test was significantly higher in the pharyngeal flora of
patients who developed streptococcal relapses after initial therapy. The organism
most frequently associated with this phenomenon was Staphylococcus aureus.
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References
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Article info
Publication history
Accepted:
September 6,
1963
Received:
July 10,
1963
With the technical assistance of LOIS MISHCONFootnotes
☆Aided in part by grants from the New York Heart Association and Eli Lilly & Company.
☆Presented in part at the American Heart Association Annual Meeting, St. Louis, Mo. October 1960.
Identification
Copyright
© 1964 Published by Elsevier Inc.
