Research Article| Volume 63, ISSUE 1, P23-29, January 1964

Pathogenesis of fever in rabbits following intravenous injection of Coxsackie virus

  • M.Kenton King
    From the Department of Preventive Medicine and the Division of Infectious Diseases of the Department of Medicine, Washington University School of Medicine St. Louis, Mo. U.S.A.
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      These experiments describe the fever produced in rabbits by Coxsackie virus grown in HeLa cells. Pyrogenic activity was not diminished following exposure of virus-cell extracts to specific antibody either in vitro or in vivo. Intravenous injection of this pyrogen into normal rabbits was followed by a sharp rise in circulating granulocytes during the second hour coincident with a fall in circulating lymphocytes. An endogenous pyrogen is described in the circulation of rabbits with fever caused by virus-cell pyrogen. These findings suggest that the mechanism of fever production in the recipient animal following intravenous injection of Coxsackie virus may be quite similar to that involved in fevers produced by bacterial pyrogens.
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