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Abstract
These experiments describe the fever produced in rabbits by Coxsackie virus grown
in HeLa cells. Pyrogenic activity was not diminished following exposure of virus-cell
extracts to specific antibody either in vitro or in vivo. Intravenous injection of
this pyrogen into normal rabbits was followed by a sharp rise in circulating granulocytes
during the second hour coincident with a fall in circulating lymphocytes. An endogenous
pyrogen is described in the circulation of rabbits with fever caused by virus-cell
pyrogen. These findings suggest that the mechanism of fever production in the recipient
animal following intravenous injection of Coxsackie virus may be quite similar to
that involved in fevers produced by bacterial pyrogens.
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References
- The Properties and Biological Effects of Bacterial Pyrogens.Medicine. 1950; 29: 365
- Bacterial Pyrogens.Pharmacol. Rev. 1957; 9: 427
- Production of Fever in Rabbits With Extracts of Tissue Culture Cells Infected With Coxsackie Virus.J. Lab. & Clin. Med. 1962; 59: 986
- Pathogenesis of Fever: Effects of Various Endogenous Pyrogens Upon the Level of Circulating Granulocytes in Normal Rabbits.J. Exper. Med. 1960; 112: 809
- A Simple Method of Estimating Fifty Per Cent End points.Am. J. Hygiene. 1938; 27: 493
- Studies on the Pathogenesis of Fever. I. The Presence of a Transferable Pyrogen in the Blood Stream Following the Injection of Typhoid Vaccine.J. Exper. Med. 1955; 101: 519
- Studies on the Pathogenesis of Fever With Influenzal Viruses. I. The Appearance of an Endogenous Pyrogen in the Blood Following Intravenous Injection of Virus.J. Exper. Med. 1958; 107: 383
- Studies on the Pathogenesis of Fever. II. Characterization of Fever-Producing Substances From Polymorphonuclear Leucocytes and From the Fluid of Sterile Exudates.J. Exper. Med. 1953; 98: 493
- Studies on the Pathogenesis of Fever. XI. Quantitative Features of the Febrile Response to Leucocytic Pyrogen.J. Exper. Med. 1963; 117: 349
- Studies on the Pathogenesis of Fever. I. The Effect of Injections of Extracts and Suspensions of Uninfected Rabbit Tissues Upon the Body Temperature of Normal Rabbits.J. Exper. Med. 1953; 98: 477
- The Pathogenesis of Fever.Am. J. Med. 1955; 18: 351
- Pathogenesis of Fever.Physiol. Rev. 1960; 40: 580
Article info
Publication history
Accepted:
September 11,
1963
Received:
August 5,
1963
Footnotes
☆This study was supported by Grant E-2232, United States Public Health Service.
Identification
Copyright
© 1964 Published by Elsevier Inc.
