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Abstract
Saline washings of the tracheobronchial tree were obtained from 12 individuals who
denied recent respiratory disease and presented no abnormalities of the respiratory
system on physical examination. By use of antisera to normal human serum components,
3 proteins were consistently identified, β2A-globulin, γ2-globulin, and albumin. Quantitation of these proteins showed that the level of β2A-globulin per milligram of albumin in the tracheobronchial fluid was 9 times the value
in serum and that the amount of γ2-globulin per milligram of albumin was similar to that in serum. It is not clear whether
the high level of β2A is derived from serum or produced locally. The role of these immunoglobulins in resistance
to infection and in allergic diseases requires investigation.
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References
- Topley and Wilson's Principles of Bacteriology and Immunity.in: Williams and Wilkins Co, Baltimore1955: 1167
- Studies in Experimental Immunology of Influenza. IV. The Protective Value of Active Immunization.Australian J. Exper. Biol. & M. Sc. 1950; 28: 61
- Immunoelectrophoresis of Nasal Secretions Collected During a Common Cold: Observations Which Suggest a Mechanism of Seroimmunity in Viral Respiratory Infections.J. Immunol. 1962; 89: 691
- Diffusion In Gel Methods for Immunologic Analysis.Prog. Allergy. 1958; 5: 1
- The Selective Occurrence of γ1A-globulin in Certain Body Fluids.J. Clin. Invest. 1963; 42: 1552
- Todd-Sanford Clinical Diagnosis by Laboratory Methods.in: W. B. Saunders Co, Philadelphia1962: 945
- The Serum γ-Globulins Defined by Electrophoretic and Immunologic Analyses.Arch. Biochem. & Biophys. 1955; 59: 33
Chodirker, W. B., and Tomasi, T. B., Jr.: Personal communication.
- Measurement and Statistics.in: Oxford University Press, New York1958: 484
- Immunochemical Studies on Protein Pathology. The Immunoglobulin Concept.Clin. chim. acta. 1959; 4: 639
- Experimental Immunochemistry.Charles C Thomas, Publisher, Springfield1961 (chapter 7)
- The Association of Skin-Sensitizing Antibody With the β2A-Globulins in Sera From Ragweed-Sensitive Patients.J. Exper. Med. 1968; 117: 603
- The Presence of the Antibody Activity in the β2A, β2M, and γ-Globulins of the Ragweed (RW)-Sensitive Individuals.in: ed. 5. Fed. Proc. 22. 1963: 326
- Studies on the Immune Globulins of Human Serum. II. A Study of the Distribution of Anti-brucella and Anti-diphtheria Antibody Activities Among γss-, γ1M-, and γ1A-Globulin Fractions.J. Immunol. 1963; 91: 11
- Specific Antibodies of Mucous Surfaces.Vet. Rev. & Annot. 1959; 5: 17
Article info
Publication history
Accepted:
September 8,
1963
Received:
July 22,
1963
Footnotes
☆This investigation was supported in part by a United States Public Health Service Training Grant, 2G-269(C2), from the Division of General Medical Sciences and by United States Public Health Service Grants HE-06415-02 and AI-02334-05.
Identification
Copyright
© 1964 Published by Elsevier Inc.