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Saline washings of the tracheobronchial tree were obtained from 12 individuals who denied recent respiratory disease and presented no abnormalities of the respiratory system on physical examination. By use of antisera to normal human serum components, 3 proteins were consistently identified, β2A-globulin, γ2-globulin, and albumin. Quantitation of these proteins showed that the level of β2A-globulin per milligram of albumin in the tracheobronchial fluid was 9 times the value in serum and that the amount of γ2-globulin per milligram of albumin was similar to that in serum. It is not clear whether the high level of β2A is derived from serum or produced locally. The role of these immunoglobulins in resistance to infection and in allergic diseases requires investigation.
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Accepted: September 8, 1963
Received: July 22, 1963
☆This investigation was supported in part by a United States Public Health Service Training Grant, 2G-269(C2), from the Division of General Medical Sciences and by United States Public Health Service Grants HE-06415-02 and AI-02334-05.
© 1964 Published by Elsevier Inc.