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Abstract
Disappearance of platelet-bound C14-labeled serotonin was studied in 1 patient with multiple sclerosis, 1 patient with
a malignant rectal carcinoid tumor, liver metastases, and normal excretion of 5-hydroxyindole
acetic acid (5-HIAA), and 5 patients with malignant gastric or intestinal carcinoid
tumors with liver metastases and elevated 5-HIAA excretion. In the subject with multiple
sclerosis, the half-life was 2.8 and 1.7 days after in vitro and in vivo labeling,
respectively. It was 4.5 days in the patient with rectal carcinoid. In the patients
with “functioning” carcinoid tumors, the half-life of platelet serotonin was short
(0.12 to 1.5 days) and varied inversely with the quantity of 5-HIAA excreted per day.
It is concluded that platelet serotonin exchanges with body depots of the amine.
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References
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Article info
Publication history
Accepted:
October 10,
1963
Received:
July 30,
1963
Footnotes
☆This work was carried out under contract AT(30-1)-2138 with the Atomic Energy Commission, and National Institutes of Health Grant CA-06297.
☆A portion of this work was presented at a Conference on Recent Developments in Studies of Blood Platelets held at Oak Ridge National Laboratory in June 1962, and an abstract appeared in Blood 20: 764 1962.
Identification
Copyright
© 1964 Published by Elsevier Inc.
