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Abstract
Normal and alloxan-diabetic rats were fed a high-fat diet. At intervals after starting
the diet, animals from each group were killed for histologic examination of the heart
and for measurement of plasma lipids and of certain coagulation factors. Both groups
of animals showed increases in the plasma concentrations of factors II, V, VII, VIII,
and X, decreases in the concentration of antithrombin and in prothrombin time, recalcification
time, and Stypven time. The changes in the 2 groups were virtually identical in degree
and time. The plasma concentrations of cholesterol, total phospholipids, and phosphatidyl
ethanolamine rose in both groups but were higher in the diabetic animals. Athcromatous
lesions developed more rapidly and were more extensive in the diabetic group. It is
concluded that insulin deficiency in the rat increases susceptibility to atheroma
formation associated with a high-fat diet, that this increase is not due to an increase
in the hypercoagulable state beyond that produced in non-diabetic rats by such a diet,
and that the clotting changes were not directly related to the plasma concentration
of total phospholipids or of phosphatidyl ethanolamine.
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Article info
Publication history
Accepted:
October 24,
1963
Received:
July 16,
1963
With the technical assistance of MYRNA AIKMAN and ADELE RUDYTEFootnotes
☆Supported by a grant from the Quebec Heart Foundation.
☆Previously presented at the meeting of the Canadian Society for Clinical Investigation, Edmonton, Alberta, Canada January 1963.
Identification
Copyright
© 1964 Published by Elsevier Inc.